Construction of a 980 nm laser-activated Pt(II) metallacycle nanosystem for efficient and safe photo-induced bacteria sterilization

Yuling Xu, Chonglu Li, Jusung An, Xin Ma, Jingfang Yang, Lishi Luo, Yun Deng, Jong Seung Kim, Yao Sun

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)

Abstract

Although metal-based chemical agents have demonstrated promising bacteriostatic effects in phototherapy, their short excitation/emission wavelengths and inadequate phototherapy efficiencies make their application in vivo difficult. We therefore synthesized a novel Pt(II) metallacycle (Pt1110) that can be activated with a 980 nm laser for photodiagnosis/treatment in deep tissue. We found that Pt1110 significantly improved photothermal conversion (95% improvement) and 1O2 generation (ΦΔ 75% increase) compared to the ligand itself 1 and was well capable of light-induced sterilization under safe laser irradiation (0.72 W/cm2). In addition, Pt1110 has little to no toxicity to cells. After incorporated into liposome, Pt1110 NPs was effective in wound healing in infection and keratitis models upon laser irradiation, which was accurately observed by NIR-II fluorescence imaging. This novel metal-coordinated supramolecular material has a potential to become a universal platform for phototherapy in deep tissue. [Figure not available: see fulltext.]

Original languageEnglish
Pages (from-to)155-163
Number of pages9
JournalScience China Chemistry
Volume66
Issue number1
DOIs
Publication statusPublished - 2023 Jan

Bibliographical note

Funding Information:
This work was supported by National Natural Science Foundation of China (22022404, 22074050, 21904103), the Fundamental Research Funds for the Central Universities (CCNU22QN007), the Open Research Fund of State Key Laboratory of Chemo/Biosensing and Chemometrics (2021005), the Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules Hubei University (KLSAOFM2111), the Opening Project of Key Laboratory of Optoelectronic Chemical Materials and Devices of Ministry of Education, Jianghan University (JDGD-202209) and the Open Project Program of Key Laboratory for Analytical Science of Food Safety and Biology, Ministry of Education (FS2202). This article was also supported by the CRI project of National Research Foundation of Republic of Korea (2018R1A3B1052702, JSK).

Publisher Copyright:
© 2022, Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature.

Keywords

  • NIR-II fluorescence imaging
  • deep penetration
  • metallacycle
  • phototheranostics
  • supramolecular chemistry

ASJC Scopus subject areas

  • General Chemistry

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