Construction of spatiotemporal infant cortical surface atlas of rhesus macaque

Fan Wang, Chunfeng Lian, Jing Xia, Zhengwang Wu, Dingna Duan, Li Wang, Dinggang Shen, Gang Li

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    12 Citations (Scopus)

    Abstract

    As a widely used animal model in MR imaging studies, rhesus macaque helps to better understand both normal and abnormal neural development in the human brain. However, the available adult macaque brain atlases are not well suitable for study of brain development at the early postnatal stage, since this stage undergoes dramatic changes in brain appearances and structures. Building age matched atlases for this critical period is thus highly desirable yet still lacking. In this paper, we construct the first spatiotemporal (4D) cortical surface atlases for rhesus macaques from 2 weeks to 24 months, using 138 longitudinal MRI scans from 32 healthy rhesus monkeys. Specifically, we first perform intra-subject cortical surface registration to obtain within-subject mean cortical surfaces. Then, we perform inter-subject registration of within-subject mean surfaces to obtain unbiased and longitudinally-consistent 4D cortical surface atlases. Based on our 4D rhesus monkey atlases, we further chart the first developmental-trajectories-based parcellation maps using the local surface area and spectral clustering algorithm. Our 4D macaque surface atlases and parcellation maps will greatly facilitate early brain development studies of macaques.

    Original languageEnglish
    Title of host publication2018 IEEE 15th International Symposium on Biomedical Imaging, ISBI 2018
    PublisherIEEE Computer Society
    Pages704-707
    Number of pages4
    ISBN (Electronic)9781538636367
    DOIs
    Publication statusPublished - 2018 May 23
    Event15th IEEE International Symposium on Biomedical Imaging, ISBI 2018 - Washington, United States
    Duration: 2018 Apr 42018 Apr 7

    Publication series

    NameProceedings - International Symposium on Biomedical Imaging
    Volume2018-April
    ISSN (Print)1945-7928
    ISSN (Electronic)1945-8452

    Other

    Other15th IEEE International Symposium on Biomedical Imaging, ISBI 2018
    Country/TerritoryUnited States
    CityWashington
    Period18/4/418/4/7

    Bibliographical note

    Publisher Copyright:
    © 2018 IEEE.

    Keywords

    • Brain development
    • Cortical surface atlas
    • Monkey
    • Parcellation
    • Rhesus macaque

    ASJC Scopus subject areas

    • Biomedical Engineering
    • Radiology Nuclear Medicine and imaging

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