TY - GEN
T1 - Construction of spatiotemporal infant cortical surface atlas of rhesus macaque
AU - Wang, Fan
AU - Lian, Chunfeng
AU - Xia, Jing
AU - Wu, Zhengwang
AU - Duan, Dingna
AU - Wang, Li
AU - Shen, Dinggang
AU - Li, Gang
N1 - Funding Information:
This work is supported in part by NIH grants: MH100217, MH108914, MH107815 and MH109773.
Publisher Copyright:
© 2018 IEEE.
PY - 2018/5/23
Y1 - 2018/5/23
N2 - As a widely used animal model in MR imaging studies, rhesus macaque helps to better understand both normal and abnormal neural development in the human brain. However, the available adult macaque brain atlases are not well suitable for study of brain development at the early postnatal stage, since this stage undergoes dramatic changes in brain appearances and structures. Building age matched atlases for this critical period is thus highly desirable yet still lacking. In this paper, we construct the first spatiotemporal (4D) cortical surface atlases for rhesus macaques from 2 weeks to 24 months, using 138 longitudinal MRI scans from 32 healthy rhesus monkeys. Specifically, we first perform intra-subject cortical surface registration to obtain within-subject mean cortical surfaces. Then, we perform inter-subject registration of within-subject mean surfaces to obtain unbiased and longitudinally-consistent 4D cortical surface atlases. Based on our 4D rhesus monkey atlases, we further chart the first developmental-trajectories-based parcellation maps using the local surface area and spectral clustering algorithm. Our 4D macaque surface atlases and parcellation maps will greatly facilitate early brain development studies of macaques.
AB - As a widely used animal model in MR imaging studies, rhesus macaque helps to better understand both normal and abnormal neural development in the human brain. However, the available adult macaque brain atlases are not well suitable for study of brain development at the early postnatal stage, since this stage undergoes dramatic changes in brain appearances and structures. Building age matched atlases for this critical period is thus highly desirable yet still lacking. In this paper, we construct the first spatiotemporal (4D) cortical surface atlases for rhesus macaques from 2 weeks to 24 months, using 138 longitudinal MRI scans from 32 healthy rhesus monkeys. Specifically, we first perform intra-subject cortical surface registration to obtain within-subject mean cortical surfaces. Then, we perform inter-subject registration of within-subject mean surfaces to obtain unbiased and longitudinally-consistent 4D cortical surface atlases. Based on our 4D rhesus monkey atlases, we further chart the first developmental-trajectories-based parcellation maps using the local surface area and spectral clustering algorithm. Our 4D macaque surface atlases and parcellation maps will greatly facilitate early brain development studies of macaques.
KW - Brain development
KW - Cortical surface atlas
KW - Monkey
KW - Parcellation
KW - Rhesus macaque
UR - http://www.scopus.com/inward/record.url?scp=85048077590&partnerID=8YFLogxK
U2 - 10.1109/ISBI.2018.8363671
DO - 10.1109/ISBI.2018.8363671
M3 - Conference contribution
AN - SCOPUS:85048077590
T3 - Proceedings - International Symposium on Biomedical Imaging
SP - 704
EP - 707
BT - 2018 IEEE 15th International Symposium on Biomedical Imaging, ISBI 2018
PB - IEEE Computer Society
T2 - 15th IEEE International Symposium on Biomedical Imaging, ISBI 2018
Y2 - 4 April 2018 through 7 April 2018
ER -