Continuous synthesis of an intermediate of quinolone antibiotic drug using static mixers

Jaehoon Choe, Yeongdae Kim, Kwang Ho Song

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


In-line static mixer technology was employed in a continuous synthesis of a pharmaceutical intermediate of new quinolone antibiotics. The reaction of interest is the protection of amine with t-Boc, and it is characterized by a fast rate and relatively high exothermicity. The heat generated from the reaction can alter the reaction pathway or destroy the structure of the products. Reaction kinetics were derived from a series of batch measurements of heat flows using an RC1 reaction calorimeter. Results showed that the heat generated from the reaction initiated a mechanism for byproduct formation, and efficient mixing and heat removal with the static mixer led to reduced byproduct formation and promoted a high yield. On the basis of the reaction kinetics, a simple plug-flow reactor model was developed for this system.

Original languageEnglish
Pages (from-to)187-190
Number of pages4
JournalOrganic Process Research and Development
Issue number2
Publication statusPublished - 2003 Mar
Externally publishedYes

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry


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