Contracted thalamic shape is associated with early development of levodopa-induced dyskinesia in Parkinson’s disease

Han Soo Yoo, Eun Chong Lee, Seok Jong Chung, Byoung Seok Ye, Young H. Sohn, Joon Kyung Seong, Phil Hyu Lee

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Levodopa-induced dyskinesia (LID), a long-term motor complication in Parkinson’s disease (PD), is attributable to both presynaptic and postsynaptic mechanisms. However, no studies have evaluated the baseline structural changes associated with LID at a subcortical level in PD. A total of 116 right-handed PD patients were recruited and based on the LID latency of 5 years, we classified patients into those vulnerable to LID (PD-vLID, n = 49) and those resistant to LID (PD-rLID, n = 67). After adjusting for covariates including dopamine transporter (DAT) availability of the posterior putamen, we compared the subcortical shape between the groups and investigated its association with the onset of LID. The PD-vLID group had lower DAT availability in the posterior putamen, higher parkinsonian motor deficits, and faster increment in levodopa equivalent dose than the PD-rLID group. The PD-vLID group had significant inward deformation in the right thalamus compared to the PD-rLID group. Inward deformation in the thalamus was associated with an earlier onset of LID at baseline. This study suggests that independent of presynaptic dopamine depletion, the thalamus is a major neural substrate for LID and that a contracted thalamic shape at baseline is closely associated with an early development of LID.

Original languageEnglish
Article number12631
JournalScientific reports
Issue number1
Publication statusPublished - 2022 Dec

Bibliographical note

Funding Information:
This work was supported by a grant from the Korea Health Technology R&D Project through the Korean Healthy Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HU21C0053) awarded to Phil Hyu Lee and by a new faculty research seed money grant of Yonsei University College of Medicine for 2022 (grant number: 2022-32-0057) awarded to Han Soo Yoo.

Publisher Copyright:
© 2022, The Author(s).

ASJC Scopus subject areas

  • General


Dive into the research topics of 'Contracted thalamic shape is associated with early development of levodopa-induced dyskinesia in Parkinson’s disease'. Together they form a unique fingerprint.

Cite this