Tandem chemical changes are often difficult to control at will, because they proceed rapidly through multiple unstable reactive intermediates. It is desirable to develop a novel method for controlling such tandem changes to obtain desired products with high selectivity. Herein, we report a flow microreactor platform for controlling tandem isomerizations of o-lithiated aryl benzyl ethers based on precise residence time control.
Bibliographical noteFunding Information:
We acknowledge the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIP) (No. 2017R1A3B1023598). This work was also supported by a Grant in-Aid for Scientific Research (S) 26220804 and a Grant-in-Aid for Young Scientists (B) 16K17898 funded by the Japan Society for the Promotion of Science (JSPS).
© 2018 The Royal Society of Chemistry.
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Ceramics and Composites
- Surfaces, Coatings and Films
- Metals and Alloys
- Materials Chemistry