Control over micro-fluidity of liposomal membranes by hybridizing metal nanoparticles

Sung Hee Park, Seong Geun Oh, Kyung Do Suh, Sang Hoon Han, Dong June Chung, Ji Young Mun, Sung Sik Han, Jin Woong Kim

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


This study introduces a facile method to hybridize metal nanoparticles with lipid vesicles, which allows us to control over their membrane micro-fluidity. We have fabricated these hybrid liposomes by directly hybridizing metal nanoparticles with lipid bilayers solely consisting of 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC). For this, we have used the dehydration and rehydration method. Characterizing their morphology and micro-fluidity, in which we have used electron microscopy and fluorescence anisotropy spectroscopy, enables us to demonstrate that metal nanoparticles with different surface properties create interactions with either phosphorus end groups or hydrophobic tails of DPPC, thereby resulting in decrease in micro-fluidity of the assembled lipid membranes, especially for the hydrophobic layers. Our approach to hybridize metal nanoparticles in between lipid layers offers a flexible means that allows us to obtain a liposome system with more controllable membrane properties.

Original languageEnglish
Pages (from-to)108-113
Number of pages6
JournalColloids and Surfaces B: Biointerfaces
Issue number1
Publication statusPublished - 2009 Apr 1


  • Hydrophobic layers
  • Interactions
  • Lipid membranes
  • Metal nanoparticles
  • Micro-fluidity

ASJC Scopus subject areas

  • Biotechnology
  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry


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