Controllable movement of the azobenzene linked crown ether conjugated liposome

Jinseok Kim; Eunseok Seo; Soohyun Kim; Sukho Park; Byungkyu Kim

doi:10.1016/j.snb.2008.06.053

Controllable movement of the azobenzene linked crown ether conjugated liposome

Jinseok Kim, Eunseok Seo, Soohyun Kim, Sukho Park, Byungkyu Kim

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

This paper is a report on our research efforts to polymerize encapsulated actin within the liposome for embodiment of a micro sized robot that mimics locomotion of an amoeba. We employed an electroporation technique to control polymerization in a liposome. In order to optimize polymerization and depolymerization in the liposome, we compared the time of polymerization and depolymerization with various concentration of crown ether. For that purpose, we synthesized the liposome which contained the azobenzene linked crown ether conjugated actin protein since azobenzene linked crown ether held the K⁺ ion by exposure of UV light. This exposure disturbed actin polymerization. As a result, the growth and degeneration of the liposome could be controlled by external stimuli which were UV light. Therefore, we could confirm the strategy is feasible to develop an amoeba-like micro robot based on control of a liposome. The major merit of the control by UV light was that we did not need to inject proteins which then induced polymerization and depolymerization of the actin protein.

Original language	English
Pages (from-to)	843-848
Number of pages	6
Journal	Sensors and Actuators, B: Chemical
Volume	134
Issue number	2
DOIs	https://doi.org/10.1016/j.snb.2008.06.053
Publication status	Published - 2008 Sept 25
Externally published	Yes

Bibliographical note

Funding Information:
This research has been supported by the Intelligent Microsystem Center (IMC; http://www.microsystem.re.kr ), which carries out one of the 21st century's Frontier R&D Projects sponsored by the Korea Ministry of Commerce, Industry and Energy. We thank the reviewers for the helpful comments and Dr. S. Adam Hacking for the proofreading.

Keywords

Actin filament
Azobenzene
Control polymerization
Crown ether
Liposome

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Instrumentation
Condensed Matter Physics
Surfaces, Coatings and Films
Metals and Alloys
Electrical and Electronic Engineering
Materials Chemistry

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10.1016/j.snb.2008.06.053

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title = "Controllable movement of the azobenzene linked crown ether conjugated liposome",

abstract = "This paper is a report on our research efforts to polymerize encapsulated actin within the liposome for embodiment of a micro sized robot that mimics locomotion of an amoeba. We employed an electroporation technique to control polymerization in a liposome. In order to optimize polymerization and depolymerization in the liposome, we compared the time of polymerization and depolymerization with various concentration of crown ether. For that purpose, we synthesized the liposome which contained the azobenzene linked crown ether conjugated actin protein since azobenzene linked crown ether held the K+ ion by exposure of UV light. This exposure disturbed actin polymerization. As a result, the growth and degeneration of the liposome could be controlled by external stimuli which were UV light. Therefore, we could confirm the strategy is feasible to develop an amoeba-like micro robot based on control of a liposome. The major merit of the control by UV light was that we did not need to inject proteins which then induced polymerization and depolymerization of the actin protein.",

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author = "Jinseok Kim and Eunseok Seo and Soohyun Kim and Sukho Park and Byungkyu Kim",

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AU - Kim, Jinseok

AU - Seo, Eunseok

AU - Kim, Soohyun

AU - Park, Sukho

AU - Kim, Byungkyu

N1 - Funding Information: This research has been supported by the Intelligent Microsystem Center (IMC; http://www.microsystem.re.kr ), which carries out one of the 21st century's Frontier R&D Projects sponsored by the Korea Ministry of Commerce, Industry and Energy. We thank the reviewers for the helpful comments and Dr. S. Adam Hacking for the proofreading.

PY - 2008/9/25

Y1 - 2008/9/25

N2 - This paper is a report on our research efforts to polymerize encapsulated actin within the liposome for embodiment of a micro sized robot that mimics locomotion of an amoeba. We employed an electroporation technique to control polymerization in a liposome. In order to optimize polymerization and depolymerization in the liposome, we compared the time of polymerization and depolymerization with various concentration of crown ether. For that purpose, we synthesized the liposome which contained the azobenzene linked crown ether conjugated actin protein since azobenzene linked crown ether held the K+ ion by exposure of UV light. This exposure disturbed actin polymerization. As a result, the growth and degeneration of the liposome could be controlled by external stimuli which were UV light. Therefore, we could confirm the strategy is feasible to develop an amoeba-like micro robot based on control of a liposome. The major merit of the control by UV light was that we did not need to inject proteins which then induced polymerization and depolymerization of the actin protein.

AB - This paper is a report on our research efforts to polymerize encapsulated actin within the liposome for embodiment of a micro sized robot that mimics locomotion of an amoeba. We employed an electroporation technique to control polymerization in a liposome. In order to optimize polymerization and depolymerization in the liposome, we compared the time of polymerization and depolymerization with various concentration of crown ether. For that purpose, we synthesized the liposome which contained the azobenzene linked crown ether conjugated actin protein since azobenzene linked crown ether held the K+ ion by exposure of UV light. This exposure disturbed actin polymerization. As a result, the growth and degeneration of the liposome could be controlled by external stimuli which were UV light. Therefore, we could confirm the strategy is feasible to develop an amoeba-like micro robot based on control of a liposome. The major merit of the control by UV light was that we did not need to inject proteins which then induced polymerization and depolymerization of the actin protein.

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KW - Control polymerization

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Controllable movement of the azobenzene linked crown ether conjugated liposome

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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