Convenient synthesis of indeno[1,2-c]isoquinolines as constrained forms of 3-arylisoquinolines and docking study of a topoisomerase I inhibitor into DNA-topoisomerase I complex

Hue Thi My Van; Quynh Manh Le; Kwang Youl Lee; Eung Seok Lee; Youngjoo Kwon; Tae Sung Kim; Thanh Nguyen Le; Suh Hee Lee; Won Jea Cho

doi:10.1016/j.bmcl.2007.08.062

Convenient synthesis of indeno[1,2-c]isoquinolines as constrained forms of 3-arylisoquinolines and docking study of a topoisomerase I inhibitor into DNA-topoisomerase I complex

Hue Thi My Van, Quynh Manh Le, Kwang Youl Lee, Eung Seok Lee, Youngjoo Kwon, Tae Sung Kim, Thanh Nguyen Le, Suh Hee Lee, Won Jea Cho

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

11-Hydroxyindeno[1,2-c]isoquinolines 12a-c were prepared as constrained forms of 3-arylisoquinolines through an intramolecular cyclization reaction. Among the synthesized compounds, the 11-ⁱbutoxy analog 15l displayed potent in vitro cytotoxicity against four different tumor cell lines as well as topoisomerase 1 inhibitory activity. A FlexX docking study was performed to explain the topoisomerase 1 activity of 15l.

Original language	English
Pages (from-to)	5763-5767
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	17
Issue number	21
DOIs	https://doi.org/10.1016/j.bmcl.2007.08.062
Publication status	Published - 2007 Nov 1

Keywords

Antitumor agents
Cytotoxicity
Docking study
Indenoisoquinoline
Synthesis
Topoisomerase 1

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2007.08.062

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Van, H. T. M., Le, Q. M., Lee, K. Y., Lee, E. S., Kwon, Y., Kim, T. S., Le, T. N., Lee, S. H., & Cho, W. J. (2007). Convenient synthesis of indeno[1,2-c]isoquinolines as constrained forms of 3-arylisoquinolines and docking study of a topoisomerase I inhibitor into DNA-topoisomerase I complex. Bioorganic and Medicinal Chemistry Letters, 17(21), 5763-5767. https://doi.org/10.1016/j.bmcl.2007.08.062

Convenient synthesis of indeno[1,2-c]isoquinolines as constrained forms of 3-arylisoquinolines and docking study of a topoisomerase I inhibitor into DNA-topoisomerase I complex. / Van, Hue Thi My; Le, Quynh Manh; Lee, Kwang Youl et al.
In: Bioorganic and Medicinal Chemistry Letters, Vol. 17, No. 21, 01.11.2007, p. 5763-5767.

Research output: Contribution to journal › Article › peer-review

Van, HTM, Le, QM, Lee, KY, Lee, ES, Kwon, Y, Kim, TS, Le, TN, Lee, SH & Cho, WJ 2007, 'Convenient synthesis of indeno[1,2-c]isoquinolines as constrained forms of 3-arylisoquinolines and docking study of a topoisomerase I inhibitor into DNA-topoisomerase I complex', Bioorganic and Medicinal Chemistry Letters, vol. 17, no. 21, pp. 5763-5767. https://doi.org/10.1016/j.bmcl.2007.08.062

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abstract = "11-Hydroxyindeno[1,2-c]isoquinolines 12a-c were prepared as constrained forms of 3-arylisoquinolines through an intramolecular cyclization reaction. Among the synthesized compounds, the 11-ibutoxy analog 15l displayed potent in vitro cytotoxicity against four different tumor cell lines as well as topoisomerase 1 inhibitory activity. A FlexX docking study was performed to explain the topoisomerase 1 activity of 15l.",

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AU - Le, Quynh Manh

AU - Lee, Kwang Youl

AU - Lee, Eung Seok

AU - Kwon, Youngjoo

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AU - Le, Thanh Nguyen

AU - Lee, Suh Hee

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Convenient synthesis of indeno[1,2-c]isoquinolines as constrained forms of 3-arylisoquinolines and docking study of a topoisomerase I inhibitor into DNA-topoisomerase I complex

Abstract

Keywords

ASJC Scopus subject areas

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