Convenient synthesis of indeno[1,2-c]isoquinolines as constrained forms of 3-arylisoquinolines and docking study of a topoisomerase I inhibitor into DNA-topoisomerase I complex

Hue Thi My Van; Quynh Manh Le; Kwang Youl Lee; Eung Seok Lee; Youngjoo Kwon; Tae Sung Kim; Thanh Nguyen Le; Suh Hee Lee; Won Jea Cho

doi:10.1016/j.bmcl.2007.08.062

Convenient synthesis of indeno[1,2-c]isoquinolines as constrained forms of 3-arylisoquinolines and docking study of a topoisomerase I inhibitor into DNA-topoisomerase I complex

Hue Thi My Van, Quynh Manh Le, Kwang Youl Lee, Eung Seok Lee, Youngjoo Kwon, Tae Sung Kim, Thanh Nguyen Le, Suh Hee Lee, Won Jea Cho

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

11-Hydroxyindeno[1,2-c]isoquinolines 12a-c were prepared as constrained forms of 3-arylisoquinolines through an intramolecular cyclization reaction. Among the synthesized compounds, the 11-ⁱbutoxy analog 15l displayed potent in vitro cytotoxicity against four different tumor cell lines as well as topoisomerase 1 inhibitory activity. A FlexX docking study was performed to explain the topoisomerase 1 activity of 15l.

Original language	English
Pages (from-to)	5763-5767
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	17
Issue number	21
DOIs	https://doi.org/10.1016/j.bmcl.2007.08.062
Publication status	Published - 2007 Nov 1

Keywords

Antitumor agents
Cytotoxicity
Docking study
Indenoisoquinoline
Synthesis
Topoisomerase 1

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2007.08.062

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Van, H. T. M., Le, Q. M., Lee, K. Y., Lee, E. S., Kwon, Y., Kim, T. S., Le, T. N., Lee, S. H., & Cho, W. J. (2007). Convenient synthesis of indeno[1,2-c]isoquinolines as constrained forms of 3-arylisoquinolines and docking study of a topoisomerase I inhibitor into DNA-topoisomerase I complex. Bioorganic and Medicinal Chemistry Letters, 17(21), 5763-5767. https://doi.org/10.1016/j.bmcl.2007.08.062

Convenient synthesis of indeno[1,2-c]isoquinolines as constrained forms of 3-arylisoquinolines and docking study of a topoisomerase I inhibitor into DNA-topoisomerase I complex. / Van, Hue Thi My; Le, Quynh Manh; Lee, Kwang Youl et al.
In: Bioorganic and Medicinal Chemistry Letters, Vol. 17, No. 21, 01.11.2007, p. 5763-5767.

Research output: Contribution to journal › Article › peer-review

Van, HTM, Le, QM, Lee, KY, Lee, ES, Kwon, Y, Kim, TS, Le, TN, Lee, SH & Cho, WJ 2007, 'Convenient synthesis of indeno[1,2-c]isoquinolines as constrained forms of 3-arylisoquinolines and docking study of a topoisomerase I inhibitor into DNA-topoisomerase I complex', Bioorganic and Medicinal Chemistry Letters, vol. 17, no. 21, pp. 5763-5767. https://doi.org/10.1016/j.bmcl.2007.08.062

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abstract = "11-Hydroxyindeno[1,2-c]isoquinolines 12a-c were prepared as constrained forms of 3-arylisoquinolines through an intramolecular cyclization reaction. Among the synthesized compounds, the 11-ibutoxy analog 15l displayed potent in vitro cytotoxicity against four different tumor cell lines as well as topoisomerase 1 inhibitory activity. A FlexX docking study was performed to explain the topoisomerase 1 activity of 15l.",

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AU - Le, Quynh Manh

AU - Lee, Kwang Youl

AU - Lee, Eung Seok

AU - Kwon, Youngjoo

AU - Kim, Tae Sung

AU - Le, Thanh Nguyen

AU - Lee, Suh Hee

AU - Cho, Won Jea

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Convenient synthesis of indeno[1,2-c]isoquinolines as constrained forms of 3-arylisoquinolines and docking study of a topoisomerase I inhibitor into DNA-topoisomerase I complex

Abstract

Keywords

ASJC Scopus subject areas

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