Conversion pattern and predictive factor of mild cognitive impairment in elderly Koreans

Sung Mi Shim, Jihyun Song, Jong Hoon Kim, Jae Pil Jeon

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


Objective: We aimed to understand conversion characteristics of mild cognitive impairment (MCI) in elderly Koreans. Methods: We analyzed clinical data of 760 individuals who participated in a two-year follow-up study. Neuropsychological assessments and clinical examination were conducted in the follow-ups. Logistic regression model was used to estimate predictive risk factors of MCI conversion. Result: The participants at baseline (n = 760) represented 462 cognitively normal individuals (60.8%), 286 individuals with MCI (37.6%), and 12 individuals with dementia (1.6%). Among the cognitively normal individuals (n = 462), 108 (23.4%) progressed to MCI during the two-year follow-up period, including 92 with amnestic mild cognitive impairment (aMCI; 19.9%) and 16 with non-amnestic mild cognitive impairment (non-aMCI; 3.5%). Interestingly, 3.7% of participants with aMCI converted to non-aMCI, while 45.5% of participants with non-aMCI converted to aMCI. Moreover, a higher proportion of non-aMCI (27.3%) reverted to a cognitively normal state, compared to aMCI participants (18.6%), indicating that non-amnestic cognitive impairment is more unstable than amnestic cognitive impairment, and probably converges toward aMCI. Additionally, we found that weight loss was associated with incident MCI and future MCI. Weight loss was negatively correlated with Clinical Dementia Rating (p = 0.005), and significantly associated with a higher risk of MCI conversion from a cognitively normal state (OR = 1.10, 95% CI: 1.00-1.21, p = 0.042). Conclusion: This study supports that non-amnestic MCI is prone to converge toward amnestic MCI, and the elderly people with weight loss are at risk for developing cognitive decline.

Original languageEnglish
Pages (from-to)146-150
Number of pages5
JournalArchives of Gerontology and Geriatrics
Publication statusPublished - 2016 May 1

Bibliographical note

Funding Information:
This study was supported by an intramural fund ( 2012-NG62002-00 ) from the Korea National Institute of Health (KNIH) of the Korea Centers for Disease Control and Prevention (KCDC). The clinical and epidemiological data used in this study were collected in support of KCDC as an extramural research program (funded to Dr. Park, MH), which was conducted in the Ansan Hospital of Korea University Medical College.

Publisher Copyright:
© 2016 Elsevier Ireland Ltd.


  • Mild cognitive impairment
  • Predictive factor
  • Weight loss

ASJC Scopus subject areas

  • Health(social science)
  • Ageing
  • Gerontology
  • Geriatrics and Gerontology


Dive into the research topics of 'Conversion pattern and predictive factor of mild cognitive impairment in elderly Koreans'. Together they form a unique fingerprint.

Cite this