Corosolic acid isolated from the fruit of Crataegus pinnatifida var. psilosa is a protein kinase C inhibitor as well as a cytotoxic agent

Kyung Seop Ahn; Moon Sun Hahm; Eun Jin Park; Hyeong Kyu Lee; Ik Hwan Kim

doi:10.1055/s-2006-957487

Corosolic acid isolated from the fruit of Crataegus pinnatifida var. psilosa is a protein kinase C inhibitor as well as a cytotoxic agent

Kyung Seop Ahn, Moon Sun Hahm, Eun Jin Park, Hyeong Kyu Lee, Ik Hwan Kim

Research output: Contribution to journal › Article › peer-review

78 Citations (Scopus)

Abstract

Corosolic acid isolated from the fruit of Crotaegus pinnotifido vat. psiloso was tested for anticancer activity. Corosolic acid displayed about the same potent cytotoxic activity as ursolic acid against several human cancer cell lines. In addition, the compound displayed antagonistic activity against the phorbol ester-induced morphological modification of 1(-562 leukemic cells, indicating the suppression of protein kinase C (PKC) activity by the cytotoxic compound. The compound showed PKC inhibition with dose- dependent pattern in an in vitro PKC assay.

Original language	English
Pages (from-to)	468-470
Number of pages	3
Journal	Planta Medica
Volume	64
Issue number	5
DOIs	https://doi.org/10.1055/s-2006-957487
Publication status	Published - 1998

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1055/s-2006-957487

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title = "Corosolic acid isolated from the fruit of Crataegus pinnatifida var. psilosa is a protein kinase C inhibitor as well as a cytotoxic agent",

abstract = "Corosolic acid isolated from the fruit of Crotaegus pinnotifido vat. psiloso was tested for anticancer activity. Corosolic acid displayed about the same potent cytotoxic activity as ursolic acid against several human cancer cell lines. In addition, the compound displayed antagonistic activity against the phorbol ester-induced morphological modification of 1(-562 leukemic cells, indicating the suppression of protein kinase C (PKC) activity by the cytotoxic compound. The compound showed PKC inhibition with dose- dependent pattern in an in vitro PKC assay.",

author = "Ahn, {Kyung Seop} and Hahm, {Moon Sun} and Park, {Eun Jin} and Lee, {Hyeong Kyu} and Kim, {Ik Hwan}",

year = "1998",

doi = "10.1055/s-2006-957487",

language = "English",

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AU - Ahn, Kyung Seop

AU - Hahm, Moon Sun

AU - Park, Eun Jin

AU - Lee, Hyeong Kyu

AU - Kim, Ik Hwan

PY - 1998

Y1 - 1998

N2 - Corosolic acid isolated from the fruit of Crotaegus pinnotifido vat. psiloso was tested for anticancer activity. Corosolic acid displayed about the same potent cytotoxic activity as ursolic acid against several human cancer cell lines. In addition, the compound displayed antagonistic activity against the phorbol ester-induced morphological modification of 1(-562 leukemic cells, indicating the suppression of protein kinase C (PKC) activity by the cytotoxic compound. The compound showed PKC inhibition with dose- dependent pattern in an in vitro PKC assay.

AB - Corosolic acid isolated from the fruit of Crotaegus pinnotifido vat. psiloso was tested for anticancer activity. Corosolic acid displayed about the same potent cytotoxic activity as ursolic acid against several human cancer cell lines. In addition, the compound displayed antagonistic activity against the phorbol ester-induced morphological modification of 1(-562 leukemic cells, indicating the suppression of protein kinase C (PKC) activity by the cytotoxic compound. The compound showed PKC inhibition with dose- dependent pattern in an in vitro PKC assay.

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VL - 64

SP - 468

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JO - Planta Medica

JF - Planta Medica

IS - 5

ER -

Corosolic acid isolated from the fruit of Crataegus pinnatifida var. psilosa is a protein kinase C inhibitor as well as a cytotoxic agent

Abstract

ASJC Scopus subject areas

UN SDGs

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