Abstract
Corosolic acid isolated from the fruit of Crotaegus pinnotifido vat. psiloso was tested for anticancer activity. Corosolic acid displayed about the same potent cytotoxic activity as ursolic acid against several human cancer cell lines. In addition, the compound displayed antagonistic activity against the phorbol ester-induced morphological modification of 1(-562 leukemic cells, indicating the suppression of protein kinase C (PKC) activity by the cytotoxic compound. The compound showed PKC inhibition with dose- dependent pattern in an in vitro PKC assay.
| Original language | English |
|---|---|
| Pages (from-to) | 468-470 |
| Number of pages | 3 |
| Journal | Planta Medica |
| Volume | 64 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 1998 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
ASJC Scopus subject areas
- Analytical Chemistry
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry
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