Correlation between impulse magnitude and inhibition of cell proliferation in alternating electric fields therapy

Geon Oh, Yunhui Jo, Yongha Gi, Jinyoung Hong, Jonghyun Kim, Boram Lee, Myonggeun Yoon

Research output: Contribution to journalArticlepeer-review

Abstract

This study was designed to investigate the correlation between the impulse by dielectrophoretic force applied inside a dividing cell during alternating electric fields therapy and the inhibition of cell proliferation. Distributions of the electric field and dielectrophoretic force inside a dividing cell were calculated using the finite element method of COMSOL Multiphysics. Based on the results, the average magnitude of the impulse by the dielectrophoretic force applied to the cleavage furrow inside a dividing cell placed in various directions was calculated as a function of electric field intensity at an extracellular reference point. The simulation results showed that the average magnitude of the impulse to the cleavage furrow inside a dividing cell ranged from 1.51 × 10−9 to 1.49 × 10−7 N s when tumor treating fields with an intensity ranging from 0.1 to 1 V/cm is applied at an extracellular reference point for 6 h. To verify the relationships between the impulse by the dielectrophoretic force and the inhibition of cell proliferation, the survival fractions of the four cancer cell lines were determined as a function of intensity and time duration of the electric field. The correlation between the magnitude and application time of the electric field and the survival fractions of the four cell lines showed similar trends in vitro. These results suggest that both the dielectrophoretic force and the time required for the force to act are proportionally related to the inhibitory effect on dividing cells, enabling this impulse to be used as a reference to quantify the inhibition of cell proliferation.

Original languageEnglish
Article number085005
JournalAIP Advances
Volume13
Issue number8
DOIs
Publication statusPublished - 2023 Aug 1

Bibliographical note

Funding Information:
This work was supported by a National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (Grant Nos. 2021R1A2C2008695 and 2022R1A2C1010337), a Korea University grant, and a Korea Medical Device Development Fund grant funded by the Government of Korea (the Ministry of Science and ICT, the Ministry of Trade, Industry and Energy, the Ministry of Health & Welfare, and the Ministry of Food and Drug Safety) (Project No. RS-2023-00254868).

Publisher Copyright:
© 2023 Author(s).

ASJC Scopus subject areas

  • General Physics and Astronomy

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