Correlation between Semi-Quantitative 18F-FDG PET/CT Parameters and Ki-67 Expression in Small Cell Lung Cancer

Soyeon Park, Eunsub Lee, Seunghong Rhee, Jaehyuk Cho, Sunju Choi, Sinae Lee, Jae Seon Eo, Kisoo Pahk, Jae Gol Choe, Sungeun Kim

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


Purpose: The aim of this study was to evaluate the relationship between semiquantitative parameters on 18F-FDG PET/CT including maximum standardized uptake value (SUVmax), mean standardized uptake value (SUVmean), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) and the expression level of Ki-67 in small-cell lung cancer (SCLC). Methods: Ninety-four consecutive patients with SCLC were enrolled in this study. They underwent 18F-FDG PET/CT for initial evaluation of SCLC, and we measured SUVmax, avgSUVmean, MTVsum, and TLGtotal on 18F-FDG PET/CT images. The protein expression of Ki-67 was examined by immunohistochemical staining. Results: Significant correlations were found between the MTVsum and Ki-67 labeling index (r = 0.254, p = 0.014) and the TLGtotal and Ki-67 labeling index (r = 0.239, p = 0.020). No correlation was found between the SUVmax and Ki-67 labeling index (r = 0.116, p = 0.264) and the avgSUVmean and Ki-67 labeling index (r = 0.031, p = 0.770). Dividing the Ki-67 expression level into three categories, it was suggested that increasing Ki-67 expression level caused a stepwise increase in the MTVsum and TLGtotal. (p = 0.028 and 0.039, respectively), but not the SUVmax and avgSUVmean (p = 0.526 and 0.729, respectively). Conclusion: In conclusion, the volume-based parameters of 18F-FDG PET/CT correlate with immunohistochemical staining of Ki-67 in SCLC. Measurement of the MTVsum and TLGtotal by 18F-FDG PET/CT might be a simple, noninvasive, and useful method to determine the proliferative potential of cancer cells.

Original languageEnglish
Pages (from-to)24-30
Number of pages7
JournalNuclear Medicine and Molecular Imaging
Issue number1
Publication statusPublished - 2016 Mar 1

Bibliographical note

Funding Information:
This study was funded by a Korea University Special Research grant, Korea University, Seoul, South Korea (no. K1507831).

Publisher Copyright:
© 2015, Korean Society of Nuclear Medicine.


  • Ki-67
  • Metabolic tumor volume
  • Small-cell lung carcinoma

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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