TY - JOUR
T1 - Correlations between umbilical and maternal serum resistin levels and neonatal birth weight
AU - Cho, Geum Joon
AU - Yoo, Sang Wook
AU - Hong, Soon Cheol
AU - Oh, Min Jeong
AU - Kim, Tak
AU - Kim, Hai Joong
AU - Lee, Kyu Wan
AU - Kim, Sun Haeng
PY - 2006/9/1
Y1 - 2006/9/1
N2 - Objective. Resistin is a novel hormone secreted by human adipocytes and mononuclear cells. It is expressed in the human placenta, and has been postulated to play a role in the regulation of energy metabolism during pregnancy. However, correlations between umbilical and maternal serum resistin levels and neonatal birth weight remain poorly understood. The purpose of the study was to clarify the correlation between umbilical cord and maternal serum resistin levels and neonatal birth weight. Materials and methods. This study included 37 healthy mothers, and their neonates. Resistin levels were determined by ELISA, and compared for correlation between umbilical cord and maternal serum resistin levels and neonatal birth weight. Results. The ranges of resistin levels for umbilical and maternal sera were 10.61-40.81 and 1.14-25.54 ng/ml, respectively. Mean umbilical serum resistin level (21.34 ± 1.07 ng/ml) was significantly higher than maternal serum resistin level (10.13 ± 1.12) (p <0.001). Umbilical serum resistin levels were positively correlated with maternal serum resistin levels (r = 0.607, p <0.001) and negatively with neonatal birth weight (r = 0.345, p = 0.037). No significant differences in resistin levels were discovered between the female and male neonates. In addition, there were no correlations between the umbilical resistin levels and maternal body mass indices, umbilical leptin levels, or insulin levels. Conclusions. It is suggested that resistin not only affects energy homeostasis by existing in high levels in the fetus, but may play an important role in controlling body weight through effective regulation of adipogenesis by negative feedback.
AB - Objective. Resistin is a novel hormone secreted by human adipocytes and mononuclear cells. It is expressed in the human placenta, and has been postulated to play a role in the regulation of energy metabolism during pregnancy. However, correlations between umbilical and maternal serum resistin levels and neonatal birth weight remain poorly understood. The purpose of the study was to clarify the correlation between umbilical cord and maternal serum resistin levels and neonatal birth weight. Materials and methods. This study included 37 healthy mothers, and their neonates. Resistin levels were determined by ELISA, and compared for correlation between umbilical cord and maternal serum resistin levels and neonatal birth weight. Results. The ranges of resistin levels for umbilical and maternal sera were 10.61-40.81 and 1.14-25.54 ng/ml, respectively. Mean umbilical serum resistin level (21.34 ± 1.07 ng/ml) was significantly higher than maternal serum resistin level (10.13 ± 1.12) (p <0.001). Umbilical serum resistin levels were positively correlated with maternal serum resistin levels (r = 0.607, p <0.001) and negatively with neonatal birth weight (r = 0.345, p = 0.037). No significant differences in resistin levels were discovered between the female and male neonates. In addition, there were no correlations between the umbilical resistin levels and maternal body mass indices, umbilical leptin levels, or insulin levels. Conclusions. It is suggested that resistin not only affects energy homeostasis by existing in high levels in the fetus, but may play an important role in controlling body weight through effective regulation of adipogenesis by negative feedback.
KW - Neonatal birth weight
KW - Umbilical cord resistin
UR - http://www.scopus.com/inward/record.url?scp=33747801144&partnerID=8YFLogxK
U2 - 10.1080/00016340500470150
DO - 10.1080/00016340500470150
M3 - Article
C2 - 16929409
AN - SCOPUS:33747801144
SN - 0001-6349
VL - 85
SP - 1051
EP - 1056
JO - Acta Obstetricia et Gynecologica Scandinavica
JF - Acta Obstetricia et Gynecologica Scandinavica
IS - 9
ER -