In the original article, there was a mistake in Figure 3 as published. It was due to an inadvertent mistake in the quantification process. The new quantification indicates that there is no statistical difference in the NMDA/AMPA ratio between WT and IRSp53-KO mice; previous Figure 3C indicated a decrease in the mutant mice. The correct Figure 3 and legend appears below. To reflect this change a correction has also been made to the Results, Emx1-Cre; Irsp53fl/fl and Viaat-Cre; Irsp53 Mice Show Distinct Changes in Synaptic Transmission and Intrinsic Excitability in mPFC Pyramidal Neurons, Second paragraph: “When evoked synaptic transmission was measured, the ratio of NMDAR-mediated EPSCs and AMPA receptor (AMPAR)-mediated EPSCs was not altered in Emx1-Cre; Irsp53fl/fl layer V pyramidal neurons (Figure 3C). These results collectively suggest that Irsp53 deletion in glutamatergic neurons leads to reduced spontaneous excitatory but not inhibitory synaptic transmission, increased ratio of evoked EPSCs/IPSCs, and increased neuronal excitability without affecting evoked NMDAR-EPSC/AMPAR-EPSC ratio in layer V mPFC neurons.” The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
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ASJC Scopus subject areas
- Cellular and Molecular Neuroscience