Coumarin-Based Small-Molecule Fluorescent Chemosensors

Duxia Cao, Zhiqiang Liu, Peter Verwilst, Seyoung Koo, Paramesh Jangjili, Jong Seung Kim, Weiying Lin

Research output: Contribution to journalArticlepeer-review

847 Citations (Scopus)


Coumarins are a very large family of compounds containing the unique 2H-chromen-2-one motif, as it is known according to IUPAC nomenclature. Coumarin derivatives are widely found in nature, especially in plants and are constituents of several essential oils. Up to now, thousands of coumarin derivatives have been isolated from nature or produced by chemists. More recently, the coumarin platform has been widely adopted in the design of small-molecule fluorescent chemosensors because of its excellent biocompatibility, strong and stable fluorescence emission, and good structural flexibility. This scaffold has found wide applications in the development of fluorescent chemosensors in the fields of molecular recognition, molecular imaging, bioorganic chemistry, analytical chemistry, materials chemistry, as well as in the biology and medical science communities. This review focuses on the important progress of coumarin-based small-molecule fluorescent chemosensors during the period of 2012-2018. This comprehensive and critical review may facilitate the development of more powerful fluorescent chemosensors for broad and exciting applications in the future.

Original languageEnglish
Pages (from-to)10403-10519
Number of pages117
JournalChemical reviews
Issue number18
Publication statusPublished - 2019 Sept 25

Bibliographical note

Funding Information:
This work was supported by the National Natural Science Foundation of China (21472067, 21672083, 21877048, and 21672130), Taishan Scholar Foundation (TS201511041), the startup fund of University of Jinan (309-10004), the Natural Science Foundation of Shandong Province (ZR2017MEM006), the China Postdoctoral Science Foundation Grant (2018M632603), the Fundamental Research Funds of Shandong University (2017JC011), the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (CRI project no. 2018R1A3B1052702, JSK), and the Korea Research Fellowship Program funded by the Ministry of Science and ICT through the NRF of Korea (2016H1D3A1938052, PV). This work was also supported by Basic Science Research Program through the NRF of Korea funded by the Ministry of Education (NRF-2017R1D1A1B03032561, PV).

Publisher Copyright:
Copyright © 2019 American Chemical Society.

ASJC Scopus subject areas

  • General Chemistry


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