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Covalent guanosine mimetic inhibitors of G12C KRAS
Yuan Xiong
, Jia Lu
, John Hunter
, Lianbo Li
, David Scott
, Hwan Geun Choi
, Sang Min Lim
, Anuj Manandhar
, Sudershan Gondi
, Taebo Sim
, Kenneth D. Westover
*
, Nathanael S. Gray
*
Corresponding author for this work
Research output
:
Contribution to journal
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Article
›
peer-review
61
Citations (Scopus)
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Keyphrases
Guanosine
100%
G12C
100%
Structure-activity Relationship
50%
Diphosphate
50%
KRAS Inhibitors
50%
Oncogene
25%
In Cancer
25%
Prodrug
25%
Cysteine
25%
Cellular Uptake
25%
Molecular Recognition
25%
Competitive Inhibitor
25%
Covalent Bond
25%
Bisphosphonates
25%
GTPase
25%
Large Families
25%
Ras Proteins
25%
Hydrolytic
25%
Difluoromethylene
25%
Hydrolytically Stable
25%
Guanosine nucleotides
25%
Stable Analogue
25%
Biochemistry, Genetics and Molecular Biology
KRAS
100%
Guanosine
100%
Pyrophosphate
66%
Enzyme
33%
Oncogene
33%
Competitive Inhibition
33%
GTPase
33%
Covalent Bond
33%
Molecular Recognition
33%
Cysteine
33%
Pharmacology, Toxicology and Pharmaceutical Science
Guanosine
100%
Pyrophosphate
66%
Malignant Neoplasm
33%
Prodrug
33%
Cysteine
33%
Guanosine Triphosphatase
33%
Covalent Bond
33%
Competitive Inhibitor
33%
Bisphosphonic Acid Derivative
33%
Ras Protein
33%