COX-2 targeting indomethacin conjugated fluorescent probe

Hyeong Seok Kim, Taegun Park, Wen Xiu Ren, Ja Yun Lim, Miae Won, June Seok Heo, Seung Gwan Lee, Jong Seung Kim

    Research output: Contribution to journalArticlepeer-review

    34 Citations (Scopus)

    Abstract

    The COX-2 targeting indomethacin-conjugated fluorescent probe IQ-1 was synthesized newly for selective fluorescence imaging of cancer cells over normal cells. IQ-1 caused stronger fluorescencc imaging of COX-2 overexpressing cancer cells (OVCAR3, HepG2 and Hela cells) than of normal cell lines (RAW 246.7 and fibroblast cells). LPS, an oxidative stress agent, treated inflamed cell lines inducing high COX-2 levels also revealed an enhanced fluorescence. In inhibitory studies, a markedly reducd fluorescence intensity was observed in cancer cells co-treated with an inhibitor, such as indomethacin and aceclofenac. Therefore, IQ-1 can be used as a selective bioimaging agent for cancer cells over normal cells, and could be developed for efficient diagnosis and therapeutic monitoring in precision medicine.

    Original languageEnglish
    Pages (from-to)261-266
    Number of pages6
    JournalDyes and Pigments
    Volume150
    DOIs
    Publication statusPublished - 2018 Mar

    Bibliographical note

    Funding Information:
    This work was supported by project grants (No. 2010-0020209 & 2009-0081566) from the Basic Science Research Program through the National Research Foundation of Korea.

    Funding Information:
    This work was supported by project grants (No. 2010-0020209 & 2009-0081566 ) from the Basic Science Research Program through the National Research Foundation of Korea .

    Publisher Copyright:
    © 2017 Elsevier Ltd

    Keywords

    • Bioimaging
    • COX-2 enzyme
    • Cancer detection
    • Fluorescent imaging
    • Indomethacin

    ASJC Scopus subject areas

    • General Chemical Engineering
    • Process Chemistry and Technology

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