Abstract
The COX-2 targeting indomethacin-conjugated fluorescent probe IQ-1 was synthesized newly for selective fluorescence imaging of cancer cells over normal cells. IQ-1 caused stronger fluorescencc imaging of COX-2 overexpressing cancer cells (OVCAR3, HepG2 and Hela cells) than of normal cell lines (RAW 246.7 and fibroblast cells). LPS, an oxidative stress agent, treated inflamed cell lines inducing high COX-2 levels also revealed an enhanced fluorescence. In inhibitory studies, a markedly reducd fluorescence intensity was observed in cancer cells co-treated with an inhibitor, such as indomethacin and aceclofenac. Therefore, IQ-1 can be used as a selective bioimaging agent for cancer cells over normal cells, and could be developed for efficient diagnosis and therapeutic monitoring in precision medicine.
Original language | English |
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Pages (from-to) | 261-266 |
Number of pages | 6 |
Journal | Dyes and Pigments |
Volume | 150 |
DOIs | |
Publication status | Published - 2018 Mar |
Bibliographical note
Funding Information:This work was supported by project grants (No. 2010-0020209 & 2009-0081566) from the Basic Science Research Program through the National Research Foundation of Korea.
Funding Information:
This work was supported by project grants (No. 2010-0020209 & 2009-0081566 ) from the Basic Science Research Program through the National Research Foundation of Korea .
Publisher Copyright:
© 2017 Elsevier Ltd
Keywords
- Bioimaging
- COX-2 enzyme
- Cancer detection
- Fluorescent imaging
- Indomethacin
ASJC Scopus subject areas
- General Chemical Engineering
- Process Chemistry and Technology