COX-2 targeting indomethacin conjugated fluorescent probe

Hyeong Seok Kim; Taegun Park; Wen Xiu Ren; Ja Yun Lim; Miae Won; June Seok Heo; Seung Gwan Lee; Jong Seung Kim

doi:10.1016/j.dyepig.2017.11.053

COX-2 targeting indomethacin conjugated fluorescent probe

Hyeong Seok Kim, Taegun Park, Wen Xiu Ren, Ja Yun Lim, Miae Won, June Seok Heo, Seung Gwan Lee, Jong Seung Kim

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

The COX-2 targeting indomethacin-conjugated fluorescent probe IQ-1 was synthesized newly for selective fluorescence imaging of cancer cells over normal cells. IQ-1 caused stronger fluorescencc imaging of COX-2 overexpressing cancer cells (OVCAR3, HepG2 and Hela cells) than of normal cell lines (RAW 246.7 and fibroblast cells). LPS, an oxidative stress agent, treated inflamed cell lines inducing high COX-2 levels also revealed an enhanced fluorescence. In inhibitory studies, a markedly reducd fluorescence intensity was observed in cancer cells co-treated with an inhibitor, such as indomethacin and aceclofenac. Therefore, IQ-1 can be used as a selective bioimaging agent for cancer cells over normal cells, and could be developed for efficient diagnosis and therapeutic monitoring in precision medicine.

Original language	English
Pages (from-to)	261-266
Number of pages	6
Journal	Dyes and Pigments
Volume	150
DOIs	https://doi.org/10.1016/j.dyepig.2017.11.053
Publication status	Published - 2018 Mar

Bibliographical note

Funding Information:
This work was supported by project grants (No. 2010-0020209 & 2009-0081566) from the Basic Science Research Program through the National Research Foundation of Korea.

Funding Information:
This work was supported by project grants (No. 2010-0020209 & 2009-0081566 ) from the Basic Science Research Program through the National Research Foundation of Korea .

Publisher Copyright:
© 2017 Elsevier Ltd

Keywords

Bioimaging
COX-2 enzyme
Cancer detection
Fluorescent imaging
Indomethacin

ASJC Scopus subject areas

General Chemical Engineering
Process Chemistry and Technology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.dyepig.2017.11.053

Cite this

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title = "COX-2 targeting indomethacin conjugated fluorescent probe",

abstract = "The COX-2 targeting indomethacin-conjugated fluorescent probe IQ-1 was synthesized newly for selective fluorescence imaging of cancer cells over normal cells. IQ-1 caused stronger fluorescencc imaging of COX-2 overexpressing cancer cells (OVCAR3, HepG2 and Hela cells) than of normal cell lines (RAW 246.7 and fibroblast cells). LPS, an oxidative stress agent, treated inflamed cell lines inducing high COX-2 levels also revealed an enhanced fluorescence. In inhibitory studies, a markedly reducd fluorescence intensity was observed in cancer cells co-treated with an inhibitor, such as indomethacin and aceclofenac. Therefore, IQ-1 can be used as a selective bioimaging agent for cancer cells over normal cells, and could be developed for efficient diagnosis and therapeutic monitoring in precision medicine.",

keywords = "Bioimaging, COX-2 enzyme, Cancer detection, Fluorescent imaging, Indomethacin",

author = "Kim, {Hyeong Seok} and Taegun Park and Ren, {Wen Xiu} and Lim, {Ja Yun} and Miae Won and Heo, {June Seok} and Lee, {Seung Gwan} and Kim, {Jong Seung}",

note = "Funding Information: This work was supported by project grants (No. 2010-0020209 & 2009-0081566) from the Basic Science Research Program through the National Research Foundation of Korea. Funding Information: This work was supported by project grants (No. 2010-0020209 & 2009-0081566 ) from the Basic Science Research Program through the National Research Foundation of Korea . Publisher Copyright: {\textcopyright} 2017 Elsevier Ltd",

year = "2018",

month = mar,

doi = "10.1016/j.dyepig.2017.11.053",

language = "English",

volume = "150",

pages = "261--266",

journal = "Dyes and Pigments",

issn = "0143-7208",

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T1 - COX-2 targeting indomethacin conjugated fluorescent probe

AU - Kim, Hyeong Seok

AU - Park, Taegun

AU - Ren, Wen Xiu

AU - Lim, Ja Yun

AU - Won, Miae

AU - Heo, June Seok

AU - Lee, Seung Gwan

AU - Kim, Jong Seung

N1 - Funding Information: This work was supported by project grants (No. 2010-0020209 & 2009-0081566) from the Basic Science Research Program through the National Research Foundation of Korea. Funding Information: This work was supported by project grants (No. 2010-0020209 & 2009-0081566 ) from the Basic Science Research Program through the National Research Foundation of Korea . Publisher Copyright: © 2017 Elsevier Ltd

PY - 2018/3

Y1 - 2018/3

N2 - The COX-2 targeting indomethacin-conjugated fluorescent probe IQ-1 was synthesized newly for selective fluorescence imaging of cancer cells over normal cells. IQ-1 caused stronger fluorescencc imaging of COX-2 overexpressing cancer cells (OVCAR3, HepG2 and Hela cells) than of normal cell lines (RAW 246.7 and fibroblast cells). LPS, an oxidative stress agent, treated inflamed cell lines inducing high COX-2 levels also revealed an enhanced fluorescence. In inhibitory studies, a markedly reducd fluorescence intensity was observed in cancer cells co-treated with an inhibitor, such as indomethacin and aceclofenac. Therefore, IQ-1 can be used as a selective bioimaging agent for cancer cells over normal cells, and could be developed for efficient diagnosis and therapeutic monitoring in precision medicine.

AB - The COX-2 targeting indomethacin-conjugated fluorescent probe IQ-1 was synthesized newly for selective fluorescence imaging of cancer cells over normal cells. IQ-1 caused stronger fluorescencc imaging of COX-2 overexpressing cancer cells (OVCAR3, HepG2 and Hela cells) than of normal cell lines (RAW 246.7 and fibroblast cells). LPS, an oxidative stress agent, treated inflamed cell lines inducing high COX-2 levels also revealed an enhanced fluorescence. In inhibitory studies, a markedly reducd fluorescence intensity was observed in cancer cells co-treated with an inhibitor, such as indomethacin and aceclofenac. Therefore, IQ-1 can be used as a selective bioimaging agent for cancer cells over normal cells, and could be developed for efficient diagnosis and therapeutic monitoring in precision medicine.

KW - Bioimaging

KW - COX-2 enzyme

KW - Cancer detection

KW - Fluorescent imaging

KW - Indomethacin

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U2 - 10.1016/j.dyepig.2017.11.053

DO - 10.1016/j.dyepig.2017.11.053

M3 - Article

AN - SCOPUS:85037972342

SN - 0143-7208

VL - 150

SP - 261

EP - 266

JO - Dyes and Pigments

JF - Dyes and Pigments

ER -

COX-2 targeting indomethacin conjugated fluorescent probe

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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