Cranberry extract with enhanced bactericidal activities against uropathogenic Escherichia coli within one minute of treatment

Sun Ae Kim, Hye Won Kim, Min Suk Rhee

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Cranberry has been widely utilized as a popular botanical dietary supplement to prevent urinary tract infection. The study aims to evaluate the enhanced bactericidal activities of cranberry against uropathogenic Escherichia coli (UPEC) by adding a small quantity of naturally derived antimicrobials. The antibacterial effect was examined with cranberry extract alone (15 and 20%), three kinds of medium-chain fatty acids alone (caprylic, capric, and lauric acid; 0.05–1.0 mM), essential oils alone (carvacrol and thymol; 0.5–1.0 mM), and cranberry extract containing medium-chain fatty acids or essential oils at 37 °C for 1 min. The survivors were remarkably reduced with cranberry extract containing any of the antimicrobials. For example, cranberry extract (15 and 20%) with 1.0 mM of each caprylic acid, lauric acid, and carvacrol resulted in the complete eradication of UPEC (7.55 log reduction). Flow cytometry analysis of UPEC cells exposed to combined treatment showed clear membrane disruption and cell death (>95% of damage). Adding antimicrobials to cranberry extract did not affect (P > 0.05) the characteristics of the cranberry extract (Color, °Brix, pH). The present method may be more acceptable to consumers, who tend to avoid products containing synthetic chemicals and prefer the use of natural agents.

Original languageEnglish
Article number108318
Publication statusPublished - 2019 Oct

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea ( NRF-2016R1A2B2012743 ). The authors also thank the School of Life Science and Biotechnology of Korea University for BK 21 PLUS , and the Institute of Biomedical Science and Food Safety, Korea University Food Safety Hall, for access to equipment and facilities.

Publisher Copyright:
© 2019 Elsevier Ltd


  • Bactericidal effect
  • Cranberry
  • Naturally derived antimicrobial
  • Uropathogenic E. coli

ASJC Scopus subject areas

  • Food Science


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