Craniomaxillofacial Bony Structures Segmentation from MRI with Deep-Supervision Adversarial Learning

Miaoyun Zhao, Li Wang, Jiawei Chen, Dong Nie, Yulai Cong, Sahar Ahmad, Angela Ho, Peng Yuan, Steve H. Fung, Hannah H. Deng, James Xia, Dinggang Shen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

35 Citations (Scopus)


Automatic segmentation of medical images finds abundant applications in clinical studies. Computed Tomography (CT) imaging plays a critical role in diagnostic and surgical planning of craniomaxillofacial (CMF) surgeries as it shows clear bony structures. However, CT imaging poses radiation risks for the subjects being scanned. Alternatively, Magnetic Resonance Imaging (MRI) is considered to be safe and provides good visualization of the soft tissues, but the bony structures appear invisible from MRI. Therefore, the segmentation of bony structures from MRI is quite challenging. In this paper, we propose a cascaded generative adversarial network with deep-supervision discriminator (Deep-supGAN) for automatic bony structures segmentation. The first block in this architecture is used to generate a high-quality CT image from an MRI, and the second block is used to segment bony structures from MRI and the generated CT image. Different from traditional discriminators, the deep-supervision discriminator distinguishes the generated CT from the ground-truth at different levels of feature maps. For segmentation, the loss is not only concentrated on the voxel level but also on the higher abstract perceptual levels. Experimental results show that the proposed method generates CT images with clearer structural details and also segments the bony structures more accurately compared with the state-of-the-art methods.

Original languageEnglish
Title of host publicationMedical Image Computing and Computer Assisted Intervention – MICCAI 2018 - 21st International Conference, 2018, Proceedings
EditorsAlejandro F. Frangi, Gabor Fichtinger, Julia A. Schnabel, Carlos Alberola-López, Christos Davatzikos
PublisherSpringer Verlag
Number of pages8
ISBN (Print)9783030009366
Publication statusPublished - 2018
Event21st International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2018 - Granada, Spain
Duration: 2018 Sept 162018 Sept 20

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume11073 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349


Other21st International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2018

Bibliographical note

Publisher Copyright:
© 2018, Springer Nature Switzerland AG.

ASJC Scopus subject areas

  • Theoretical Computer Science
  • General Computer Science


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