Creation of hierarchical micro/nano-porous TiO2 surface layer onto Ti implants for improved biocompatibility

Cheol Min Han; Hyoun Ee Kim; Young Hag Koh

doi:10.1016/j.surfcoat.2014.04.030

Creation of hierarchical micro/nano-porous TiO₂ surface layer onto Ti implants for improved biocompatibility

Cheol Min Han, Hyoun Ee Kim, Young Hag Koh

School of Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

We created a hierarchical micro/nano-porous TiO₂ surface layer onto a Ti substrate to enhance its biocompatibility by mimicking the hierarchical architecture of the native extracellular matrix. To accomplish this, a rough, micro-porous TiO₂ layer with pore sizes in the range of 0.5-2μm was first formed on the surfaces of a Ti substrate using micro-arc oxidation (MAO) and then coated with a thin layer of pure Ti, ~0.5μm in thickness, using electron beam (e-beam) evaporation. Subsequently, anodic oxidation was conducted to create a uniform nano-porous TiO₂ surface layer with a pore size of ~70nm on the micro-porous layer. This hierarchical micro/nano-porous surface showed considerably enhanced hydrophilicity and in vitro biocompatibility compared to the dense surface and even the micro-porous and nano-porous surfaces. These improvements were attributed to the synergistic effect of micropores and nanopores created by a combination of MAO and anodic oxidation. In addition, protein adsorption capacity was remarkably improved due to the high affinity of the nano-porous TiO₂ surface for proteins.

Original language	English
Pages (from-to)	226-231
Number of pages	6
Journal	Surface and Coatings Technology
Volume	251
DOIs	https://doi.org/10.1016/j.surfcoat.2014.04.030
Publication status	Published - 2014 Jul 25

Bibliographical note

Funding Information:
This research was supported by the Technology Innovation Program (Contract No. 10037915, WPM Biomedical Materials — Implant Materials) funded by the Ministry of Knowledge Economy (MKE, Korea).

Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.

Keywords

Anodic oxidation
Biocompatibility
E-beam coating
Porous surface
Protein delivery

ASJC Scopus subject areas

Chemistry(all)
Condensed Matter Physics
Surfaces and Interfaces
Surfaces, Coatings and Films
Materials Chemistry

Access to Document

10.1016/j.surfcoat.2014.04.030

Cite this

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title = "Creation of hierarchical micro/nano-porous TiO2 surface layer onto Ti implants for improved biocompatibility",

abstract = "We created a hierarchical micro/nano-porous TiO2 surface layer onto a Ti substrate to enhance its biocompatibility by mimicking the hierarchical architecture of the native extracellular matrix. To accomplish this, a rough, micro-porous TiO2 layer with pore sizes in the range of 0.5-2μm was first formed on the surfaces of a Ti substrate using micro-arc oxidation (MAO) and then coated with a thin layer of pure Ti, ~0.5μm in thickness, using electron beam (e-beam) evaporation. Subsequently, anodic oxidation was conducted to create a uniform nano-porous TiO2 surface layer with a pore size of ~70nm on the micro-porous layer. This hierarchical micro/nano-porous surface showed considerably enhanced hydrophilicity and in vitro biocompatibility compared to the dense surface and even the micro-porous and nano-porous surfaces. These improvements were attributed to the synergistic effect of micropores and nanopores created by a combination of MAO and anodic oxidation. In addition, protein adsorption capacity was remarkably improved due to the high affinity of the nano-porous TiO2 surface for proteins.",

keywords = "Anodic oxidation, Biocompatibility, E-beam coating, Porous surface, Protein delivery",

author = "Han, {Cheol Min} and Kim, {Hyoun Ee} and Koh, {Young Hag}",

note = "Funding Information: This research was supported by the Technology Innovation Program (Contract No. 10037915, WPM Biomedical Materials — Implant Materials) funded by the Ministry of Knowledge Economy (MKE, Korea). Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

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AU - Han, Cheol Min

AU - Kim, Hyoun Ee

AU - Koh, Young Hag

N1 - Funding Information: This research was supported by the Technology Innovation Program (Contract No. 10037915, WPM Biomedical Materials — Implant Materials) funded by the Ministry of Knowledge Economy (MKE, Korea). Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

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N2 - We created a hierarchical micro/nano-porous TiO2 surface layer onto a Ti substrate to enhance its biocompatibility by mimicking the hierarchical architecture of the native extracellular matrix. To accomplish this, a rough, micro-porous TiO2 layer with pore sizes in the range of 0.5-2μm was first formed on the surfaces of a Ti substrate using micro-arc oxidation (MAO) and then coated with a thin layer of pure Ti, ~0.5μm in thickness, using electron beam (e-beam) evaporation. Subsequently, anodic oxidation was conducted to create a uniform nano-porous TiO2 surface layer with a pore size of ~70nm on the micro-porous layer. This hierarchical micro/nano-porous surface showed considerably enhanced hydrophilicity and in vitro biocompatibility compared to the dense surface and even the micro-porous and nano-porous surfaces. These improvements were attributed to the synergistic effect of micropores and nanopores created by a combination of MAO and anodic oxidation. In addition, protein adsorption capacity was remarkably improved due to the high affinity of the nano-porous TiO2 surface for proteins.

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