Abstract
We created a hierarchical micro/nano-porous TiO2 surface layer onto a Ti substrate to enhance its biocompatibility by mimicking the hierarchical architecture of the native extracellular matrix. To accomplish this, a rough, micro-porous TiO2 layer with pore sizes in the range of 0.5-2μm was first formed on the surfaces of a Ti substrate using micro-arc oxidation (MAO) and then coated with a thin layer of pure Ti, ~0.5μm in thickness, using electron beam (e-beam) evaporation. Subsequently, anodic oxidation was conducted to create a uniform nano-porous TiO2 surface layer with a pore size of ~70nm on the micro-porous layer. This hierarchical micro/nano-porous surface showed considerably enhanced hydrophilicity and in vitro biocompatibility compared to the dense surface and even the micro-porous and nano-porous surfaces. These improvements were attributed to the synergistic effect of micropores and nanopores created by a combination of MAO and anodic oxidation. In addition, protein adsorption capacity was remarkably improved due to the high affinity of the nano-porous TiO2 surface for proteins.
| Original language | English |
|---|---|
| Pages (from-to) | 226-231 |
| Number of pages | 6 |
| Journal | Surface and Coatings Technology |
| Volume | 251 |
| DOIs | |
| Publication status | Published - 2014 Jul 25 |
Bibliographical note
Funding Information:This research was supported by the Technology Innovation Program (Contract No. 10037915, WPM Biomedical Materials — Implant Materials) funded by the Ministry of Knowledge Economy (MKE, Korea).
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
Keywords
- Anodic oxidation
- Biocompatibility
- E-beam coating
- Porous surface
- Protein delivery
ASJC Scopus subject areas
- General Chemistry
- Condensed Matter Physics
- Surfaces and Interfaces
- Surfaces, Coatings and Films
- Materials Chemistry