CRISPR/Cas9 assisted stem cell therapy in Parkinson's disease

Poojitha Pinjala, Kamatham Pushpa Tryphena, Renuka Prasad, Dharmendra Kumar Khatri, Woong Sun, Shashi Bala Singh, Dalapathi Gugulothu, Saurabh Srivastava, Lalitkumar Vora

Research output: Contribution to journalReview articlepeer-review

11 Citations (Scopus)

Abstract

Since its discovery in 2012, CRISPR Cas9 has been tried as a direct treatment approach to correct the causative gene mutation and establish animal models in neurodegenerative disorders. Since no strategy developed until now could completely cure Parkinson's disease (PD), neuroscientists aspire to use gene editing technology, especially CRISPR/Cas9, to induce a permanent correction in genetic PD patients expressing mutated genes. Over the years, our understanding of stem cell biology has improved. Scientists have developed personalized cell therapy using CRISPR/Cas9 to edit embryonic and patient-derived stem cells ex-vivo. This review details the importance of CRISPR/Cas9-based stem cell therapy in Parkinson's disease in developing PD disease models and developing therapeutic strategies after elucidating the possible pathophysiological mechanisms. Graphical Abstract: [Figure not available: see fulltext.].

Original languageEnglish
Article number46
JournalBiomaterials Research
Volume27
Issue number1
DOIs
Publication statusPublished - 2023 May

Bibliographical note

Publisher Copyright:
© 2023, The Author(s).

Keywords

  • Disease model
  • Embryonic stem cells
  • Gene editing
  • Human pluripotent stem cells
  • Neurodegenerative disorder
  • α-synuclein

ASJC Scopus subject areas

  • Ceramics and Composites
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering

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