Cross-reactive humoral immunity of clade 2 Oka and MAV/06 strain-based varicella vaccines against different clades of varicella–zoster virus

Ji Young Hwang; Yunhwa Kim; Kyung Min Lee; Ok Sarah Shin; Jeong An Gim; Younchul Shin; Hosun Park

doi:10.1080/21645515.2023.2210961

Cross-reactive humoral immunity of clade 2 Oka and MAV/06 strain-based varicella vaccines against different clades of varicella–zoster virus

Ji Young Hwang, Yunhwa Kim, Kyung Min Lee, Ok Sarah Shin, Jeong An Gim, Younchul Shin, Hosun Park

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

The currently used Japanese Oka and Korean MAV/06-attenuated varicella vaccine strains belong to clade 2 genotype varicella–zoster viruses (VZV). More than seven clades of VZV exist worldwide. In this study, we investigated the cross-reactivity of antibodies induced by clade 2 genotype vaccines against VZV strains belonging to clades 1, 2, 3, and 5 using a fluorescent antibody to membrane antigen (FAMA) test. Among 59 donors, 29 were vaccinated with the MAV/06 strain MG1111 (GC Biopharma, South Korea) and the other 30 were vaccinated with the Oka strain VARIVAX (Merck, USA). The sera were titrated using FAMA tests prepared with six different VZV strains (two vaccine strains, one wild-type clade 2 strain, and one each of clade 1, 3, and 5 strains). The ranges of geometric mean titers (GMTs) of FAMA against six different strains were 158.7–206.5 and 157.6–238.9 in MG1111 and VARIVAX groups, respectively. GMTs of the MG1111 group against all six strains were similar; however, GMTs of the VARIVAX group showed differences of approximately 1.5-fold depending on the strains. Nevertheless, the GMTs of the two vaccinated groups for the same strain were not significantly different. These results suggest that both MG1111 and VARIVAX vaccinations induce cross-reactive humoral immunity against other clades of VZV.

Original language	English
Article number	2210961
Journal	Human Vaccines and Immunotherapeutics
Volume	19
Issue number	1
DOIs	https://doi.org/10.1080/21645515.2023.2210961
Publication status	Published - 2023
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported by a research funding from GC BioPharma. The authors thank Dr Andreas Sauerbrei (Jena University, Germany) for providing VZV strains used in this study.

Publisher Copyright:
© 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.

Keywords

FAMA test
cross-reactivity
genotype
immunogenicity
vaccine strain
varicella

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Pharmacology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/21645515.2023.2210961

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title = "Cross-reactive humoral immunity of clade 2 Oka and MAV/06 strain-based varicella vaccines against different clades of varicella–zoster virus",

abstract = "The currently used Japanese Oka and Korean MAV/06-attenuated varicella vaccine strains belong to clade 2 genotype varicella–zoster viruses (VZV). More than seven clades of VZV exist worldwide. In this study, we investigated the cross-reactivity of antibodies induced by clade 2 genotype vaccines against VZV strains belonging to clades 1, 2, 3, and 5 using a fluorescent antibody to membrane antigen (FAMA) test. Among 59 donors, 29 were vaccinated with the MAV/06 strain MG1111 (GC Biopharma, South Korea) and the other 30 were vaccinated with the Oka strain VARIVAX (Merck, USA). The sera were titrated using FAMA tests prepared with six different VZV strains (two vaccine strains, one wild-type clade 2 strain, and one each of clade 1, 3, and 5 strains). The ranges of geometric mean titers (GMTs) of FAMA against six different strains were 158.7–206.5 and 157.6–238.9 in MG1111 and VARIVAX groups, respectively. GMTs of the MG1111 group against all six strains were similar; however, GMTs of the VARIVAX group showed differences of approximately 1.5-fold depending on the strains. Nevertheless, the GMTs of the two vaccinated groups for the same strain were not significantly different. These results suggest that both MG1111 and VARIVAX vaccinations induce cross-reactive humoral immunity against other clades of VZV.",

keywords = "FAMA test, cross-reactivity, genotype, immunogenicity, vaccine strain, varicella",

author = "Hwang, {Ji Young} and Yunhwa Kim and Lee, {Kyung Min} and Shin, {Ok Sarah} and Gim, {Jeong An} and Younchul Shin and Hosun Park",

note = "Funding Information: This work was supported by a research funding from GC BioPharma. The authors thank Dr Andreas Sauerbrei (Jena University, Germany) for providing VZV strains used in this study. Publisher Copyright: {\textcopyright} 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.",

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doi = "10.1080/21645515.2023.2210961",

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AU - Shin, Ok Sarah

AU - Gim, Jeong An

AU - Shin, Younchul

AU - Park, Hosun

N1 - Funding Information: This work was supported by a research funding from GC BioPharma. The authors thank Dr Andreas Sauerbrei (Jena University, Germany) for providing VZV strains used in this study. Publisher Copyright: © 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.

PY - 2023

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N2 - The currently used Japanese Oka and Korean MAV/06-attenuated varicella vaccine strains belong to clade 2 genotype varicella–zoster viruses (VZV). More than seven clades of VZV exist worldwide. In this study, we investigated the cross-reactivity of antibodies induced by clade 2 genotype vaccines against VZV strains belonging to clades 1, 2, 3, and 5 using a fluorescent antibody to membrane antigen (FAMA) test. Among 59 donors, 29 were vaccinated with the MAV/06 strain MG1111 (GC Biopharma, South Korea) and the other 30 were vaccinated with the Oka strain VARIVAX (Merck, USA). The sera were titrated using FAMA tests prepared with six different VZV strains (two vaccine strains, one wild-type clade 2 strain, and one each of clade 1, 3, and 5 strains). The ranges of geometric mean titers (GMTs) of FAMA against six different strains were 158.7–206.5 and 157.6–238.9 in MG1111 and VARIVAX groups, respectively. GMTs of the MG1111 group against all six strains were similar; however, GMTs of the VARIVAX group showed differences of approximately 1.5-fold depending on the strains. Nevertheless, the GMTs of the two vaccinated groups for the same strain were not significantly different. These results suggest that both MG1111 and VARIVAX vaccinations induce cross-reactive humoral immunity against other clades of VZV.

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Cross-reactive humoral immunity of clade 2 Oka and MAV/06 strain-based varicella vaccines against different clades of varicella–zoster virus

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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