Cross-reactive humoral immunity of clade 2 Oka and MAV/06 strain-based varicella vaccines against different clades of varicella–zoster virus

Ji Young Hwang, Yunhwa Kim, Kyung Min Lee, Ok Sarah Shin, Jeong An Gim, Younchul Shin, Hosun Park

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1 Citation (Scopus)


The currently used Japanese Oka and Korean MAV/06-attenuated varicella vaccine strains belong to clade 2 genotype varicella–zoster viruses (VZV). More than seven clades of VZV exist worldwide. In this study, we investigated the cross-reactivity of antibodies induced by clade 2 genotype vaccines against VZV strains belonging to clades 1, 2, 3, and 5 using a fluorescent antibody to membrane antigen (FAMA) test. Among 59 donors, 29 were vaccinated with the MAV/06 strain MG1111 (GC Biopharma, South Korea) and the other 30 were vaccinated with the Oka strain VARIVAX (Merck, USA). The sera were titrated using FAMA tests prepared with six different VZV strains (two vaccine strains, one wild-type clade 2 strain, and one each of clade 1, 3, and 5 strains). The ranges of geometric mean titers (GMTs) of FAMA against six different strains were 158.7–206.5 and 157.6–238.9 in MG1111 and VARIVAX groups, respectively. GMTs of the MG1111 group against all six strains were similar; however, GMTs of the VARIVAX group showed differences of approximately 1.5-fold depending on the strains. Nevertheless, the GMTs of the two vaccinated groups for the same strain were not significantly different. These results suggest that both MG1111 and VARIVAX vaccinations induce cross-reactive humoral immunity against other clades of VZV.

Original languageEnglish
Article number2210961
JournalHuman Vaccines and Immunotherapeutics
Issue number1
Publication statusPublished - 2023
Externally publishedYes

Bibliographical note

Funding Information:
This work was supported by a research funding from GC BioPharma. The authors thank Dr Andreas Sauerbrei (Jena University, Germany) for providing VZV strains used in this study.

Publisher Copyright:
© 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.


  • FAMA test
  • cross-reactivity
  • genotype
  • immunogenicity
  • vaccine strain
  • varicella

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology


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