Crosstalk between translation and the aggresome–autophagy pathway

Yeonkyoung Park, Joori Park, Yoon Ki Kim

Research output: Contribution to journalComment/debatepeer-review

25 Citations (Scopus)


Many neurodegenerative disorders feature the presence of misfolded polypeptide-containing intracellular inclusion bodies biochemically and morphologically analogous to cellular aggresomes. However, it is largely unknown how misfolded polypeptides form aggresomes and are eventually cleared by the aggresome-macroautophagy/autophagy pathway, so-called aggrephagy. Our recent study revealed that when the ubiquitin-proteasome system is impaired, the accumulated misfolded polypeptides are selectively recognized and transported to the aggresome by a CED complex. This complex is composed of CTIF, originally identified as a specific factor for nuclear cap-binding protein complex (a heterodimer of NCBP1/CBP80 and NCBP2/CBP20)-dependent translation (CT), and its associated factors EEF1A1 and DCTN1. Aggresomal targeting of a misfolded polypeptide via the CED complex is accompanied by CTIF release from the CT complex and thereby inhibits CT efficiency. Therefore, our study provides new mechanistic insights into the crosstalk between translational inhibition and aggresome formation under the influence of a misfolded polypeptide.

Original languageEnglish
Pages (from-to)1079-1081
Number of pages3
Issue number6
Publication statusPublished - 2018 Jun 3

Bibliographical note

Publisher Copyright:
© 2017, © 2017 Taylor and Francis Group, LLC.


  • CTIF
  • DCTN1
  • EEF1A1
  • NCBP1/CBP80
  • NCBP2/CBP20
  • aggrephagy
  • aggresome
  • autophagy
  • misfolded polypeptide

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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