Curcumin-Eudragit® e PO solid dispersion: A simple and potent method to solve the problems of curcumin

Jinglei Li; Il Woo Lee; Gye Hwa Shin; Xiguang Chen; Hyun Jin Park

doi:10.1016/j.ejpb.2015.06.002

Curcumin-Eudragit® e PO solid dispersion: A simple and potent method to solve the problems of curcumin

Jinglei Li, Il Woo Lee, Gye Hwa Shin, Xiguang Chen, Hyun Jin Park

Research output: Contribution to journal › Article › peer-review

140 Citations (Scopus)

Abstract

Using a simple solution mixing method, curcumin was dispersed in the matrix of Eudragit® E PO polymer. Water solubility of curcumin in curcumin-Eudragit® E PO solid dispersion (Cur@EPO) was greatly increased. Based on the results of several tests, curcumin was demonstrated to exist in the polymer matrix in amorphous state. The interaction between curcumin and the polymer was investigated through Fourier transform infrared spectroscopy and ¹ H NMR which implied that OH group of curcumin and carbonyl group of the polymer involved in the H bonding formation. Cur@EPO also provided protection function for curcumin as verified by the pH challenge and UV irradiation test. The pH value influenced curcumin release profile in which sustained release pattern was revealed. Additionally, in vitro transdermal test was conducted to assess the potential of Cur@EPO as a vehicle to deliver curcumin through this alternative administration route.

Original language	English
Pages (from-to)	322-332
Number of pages	11
Journal	European Journal of Pharmaceutics and Biopharmaceutics
Volume	94
DOIs	https://doi.org/10.1016/j.ejpb.2015.06.002
Publication status	Published - 2015 Jun 22

Bibliographical note

Funding Information:
This research was supported by Kyung-Nong Company , the International Research & Development Program of the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (MEST) of Korea (Grant No. 2012K1A3A1A20031356 ), a Korea University grant and Institute of Biomedical Science & Food Safety, Korea University Food Safety Hall.

Publisher Copyright:
© 2015 Elsevier B.V. All rights reserved.

Keywords

Curcumin
Eudragit®l E PO
Solid dispersion
Stability
Transdermal administration
Water solubility

ASJC Scopus subject areas

Biotechnology
Pharmaceutical Science

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10.1016/j.ejpb.2015.06.002

Cite this

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title = "Curcumin-Eudragit{\textregistered} e PO solid dispersion: A simple and potent method to solve the problems of curcumin",

abstract = " Using a simple solution mixing method, curcumin was dispersed in the matrix of Eudragit{\textregistered} E PO polymer. Water solubility of curcumin in curcumin-Eudragit{\textregistered} E PO solid dispersion (Cur@EPO) was greatly increased. Based on the results of several tests, curcumin was demonstrated to exist in the polymer matrix in amorphous state. The interaction between curcumin and the polymer was investigated through Fourier transform infrared spectroscopy and 1 H NMR which implied that OH group of curcumin and carbonyl group of the polymer involved in the H bonding formation. Cur@EPO also provided protection function for curcumin as verified by the pH challenge and UV irradiation test. The pH value influenced curcumin release profile in which sustained release pattern was revealed. Additionally, in vitro transdermal test was conducted to assess the potential of Cur@EPO as a vehicle to deliver curcumin through this alternative administration route. ",

keywords = "Curcumin, Eudragit{\textregistered}l E PO, Solid dispersion, Stability, Transdermal administration, Water solubility",

author = "Jinglei Li and Lee, {Il Woo} and Shin, {Gye Hwa} and Xiguang Chen and Park, {Hyun Jin}",

note = "Funding Information: This research was supported by Kyung-Nong Company , the International Research & Development Program of the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (MEST) of Korea (Grant No. 2012K1A3A1A20031356 ), a Korea University grant and Institute of Biomedical Science & Food Safety, Korea University Food Safety Hall. Publisher Copyright: {\textcopyright} 2015 Elsevier B.V. All rights reserved.",

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AU - Chen, Xiguang

AU - Park, Hyun Jin

N1 - Funding Information: This research was supported by Kyung-Nong Company , the International Research & Development Program of the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (MEST) of Korea (Grant No. 2012K1A3A1A20031356 ), a Korea University grant and Institute of Biomedical Science & Food Safety, Korea University Food Safety Hall. Publisher Copyright: © 2015 Elsevier B.V. All rights reserved.

PY - 2015/6/22

Y1 - 2015/6/22

N2 - Using a simple solution mixing method, curcumin was dispersed in the matrix of Eudragit® E PO polymer. Water solubility of curcumin in curcumin-Eudragit® E PO solid dispersion (Cur@EPO) was greatly increased. Based on the results of several tests, curcumin was demonstrated to exist in the polymer matrix in amorphous state. The interaction between curcumin and the polymer was investigated through Fourier transform infrared spectroscopy and 1 H NMR which implied that OH group of curcumin and carbonyl group of the polymer involved in the H bonding formation. Cur@EPO also provided protection function for curcumin as verified by the pH challenge and UV irradiation test. The pH value influenced curcumin release profile in which sustained release pattern was revealed. Additionally, in vitro transdermal test was conducted to assess the potential of Cur@EPO as a vehicle to deliver curcumin through this alternative administration route.

AB - Using a simple solution mixing method, curcumin was dispersed in the matrix of Eudragit® E PO polymer. Water solubility of curcumin in curcumin-Eudragit® E PO solid dispersion (Cur@EPO) was greatly increased. Based on the results of several tests, curcumin was demonstrated to exist in the polymer matrix in amorphous state. The interaction between curcumin and the polymer was investigated through Fourier transform infrared spectroscopy and 1 H NMR which implied that OH group of curcumin and carbonyl group of the polymer involved in the H bonding formation. Cur@EPO also provided protection function for curcumin as verified by the pH challenge and UV irradiation test. The pH value influenced curcumin release profile in which sustained release pattern was revealed. Additionally, in vitro transdermal test was conducted to assess the potential of Cur@EPO as a vehicle to deliver curcumin through this alternative administration route.

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KW - Transdermal administration

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Curcumin-Eudragit® e PO solid dispersion: A simple and potent method to solve the problems of curcumin

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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