Covering: 1994 to 2019 Owing to the rapid increase in nosocomial infections by antibiotic-resistant Acinetobacter baumannii and the paucity of effective treatment options for such infections, interest in the virulence factors involved in its successful dissemination and propagation in the human host have escalated in recent years. Acinetobacin, a siderophore of A. baumannii, is responsible for iron acquisition under nutritional depravation and has been shown to be one of the key virulence factors for this bacterium. In this Highlight, recent findings regarding various chemical and biological aspects of acinetobactin metabolism closely related to the fitness of A. baumannii at the infection sites have been described. In addition, several notable efforts for identifying novel anti-infectious agents based thereon have been discussed.
Bibliographical noteFunding Information:
This work was supported by grants from the National Research Foundation of Korea (NRF-2018R1D1A1A02086039) and the Korea Basic Science Institute (KBSI) National Research Facilities & Equipment Center (NFEC), funded by the Korea government (Ministry of Education) (2019R1A6C1010028). Protein images in Fig. 6 were produced with UCSF Chimera, developed by the Resource for Biocomputing, Visualization, and Informatics at the University of California, San Francisco, with support from NIH P41-GM103311.50
© 2020 The Royal Society of Chemistry.
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry