Current role of selective internal radiation with yttrium-90 in liver tumors

Wan Yee Lau; Yee Leong Teoh; Khin Maung Win; Rheun Chuan Lee; Vanessa H. De Villa; Yun Hwan Kim; Po Chin Liang; Ramon S. Santos-Ocampo; Richard Hoau Gong Lo; Kieron Boon Leng Lim; David Wai Meng Tai; David Chee Eng Ng; Farah Gillan Irani; Apoorva Gogna; Pierce Kah Hoe Chow

doi:10.2217/fon-2016-0035

Current role of selective internal radiation with yttrium-90 in liver tumors

Wan Yee Lau, Yee Leong Teoh, Khin Maung Win, Rheun Chuan Lee, Vanessa H. De Villa, Yun Hwan Kim, Po Chin Liang, Ramon S. Santos-Ocampo, Richard Hoau Gong Lo, Kieron Boon Leng Lim, David Wai Meng Tai, David Chee Eng Ng, Farah Gillan Irani, Apoorva Gogna, Pierce Kah Hoe Chow

Research output: Contribution to journal › Review article › peer-review

14 Citations (Scopus)

Abstract

An expert panel met to review the evidence for selective internal radiation therapy (SIRT) using yttrium-90 microspheres in hepatocellular carcinoma and metastases from colorectal cancer and neuroendocrine tumors. There is now convincing evidence for the safety and efficacy of SIRT in these situations albeit mostly from retrospective cohort studies. There are a number of ongoing prospective randomized controlled clinical trials investigating the role of SIRT in liver tumors; however, data from these trials are still several years away (although the SIRFLOX study has been recently published). In this evolving environment, published evidence and the authors' experience were used to summarize the current and potential role of SIRT in the management of hepatocellular carcinoma of intermediate or advanced stage and in liver-dominant metastatic colorectal cancer and metastatic neuroendocrine tumors.

Original language	English
Pages (from-to)	1193-1204
Number of pages	12
Journal	Future Oncology
Volume	12
Issue number	9
DOIs	https://doi.org/10.2217/fon-2016-0035
Publication status	Published - 2016 May 1

Keywords

liver cancer
selective internal radiation
transarterial chemoembolization
yttrium 90 microspheres

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.2217/fon-2016-0035

Cite this

Lau, W. Y., Teoh, Y. L., Win, K. M., Lee, R. C., De Villa, V. H., Kim, Y. H., Liang, P. C., Santos-Ocampo, R. S., Lo, R. H. G., Lim, K. B. L., Tai, D. W. M., Ng, D. C. E., Irani, F. G., Gogna, A., & Chow, P. K. H. (2016). Current role of selective internal radiation with yttrium-90 in liver tumors. Future Oncology, 12(9), 1193-1204. https://doi.org/10.2217/fon-2016-0035

@article{358395cbb2094e90a017cd227ed43201,

title = "Current role of selective internal radiation with yttrium-90 in liver tumors",

abstract = "An expert panel met to review the evidence for selective internal radiation therapy (SIRT) using yttrium-90 microspheres in hepatocellular carcinoma and metastases from colorectal cancer and neuroendocrine tumors. There is now convincing evidence for the safety and efficacy of SIRT in these situations albeit mostly from retrospective cohort studies. There are a number of ongoing prospective randomized controlled clinical trials investigating the role of SIRT in liver tumors; however, data from these trials are still several years away (although the SIRFLOX study has been recently published). In this evolving environment, published evidence and the authors' experience were used to summarize the current and potential role of SIRT in the management of hepatocellular carcinoma of intermediate or advanced stage and in liver-dominant metastatic colorectal cancer and metastatic neuroendocrine tumors.",

keywords = "liver cancer, selective internal radiation, transarterial chemoembolization, yttrium 90 microspheres",

author = "Lau, {Wan Yee} and Teoh, {Yee Leong} and Win, {Khin Maung} and Lee, {Rheun Chuan} and {De Villa}, {Vanessa H.} and Kim, {Yun Hwan} and Liang, {Po Chin} and Santos-Ocampo, {Ramon S.} and Lo, {Richard Hoau Gong} and Lim, {Kieron Boon Leng} and Tai, {David Wai Meng} and Ng, {David Chee Eng} and Irani, {Farah Gillan} and Apoorva Gogna and Chow, {Pierce Kah Hoe}",

year = "2016",

month = may,

day = "1",

doi = "10.2217/fon-2016-0035",

language = "English",

volume = "12",

pages = "1193--1204",

journal = "Future Oncology",

issn = "1479-6694",

publisher = "Future Medicine Ltd.",

number = "9",

}

TY - JOUR

T1 - Current role of selective internal radiation with yttrium-90 in liver tumors

AU - Lau, Wan Yee

AU - Teoh, Yee Leong

AU - Win, Khin Maung

AU - Lee, Rheun Chuan

AU - De Villa, Vanessa H.

AU - Kim, Yun Hwan

AU - Liang, Po Chin

AU - Santos-Ocampo, Ramon S.

AU - Lo, Richard Hoau Gong

AU - Lim, Kieron Boon Leng

AU - Tai, David Wai Meng

AU - Ng, David Chee Eng

AU - Irani, Farah Gillan

AU - Gogna, Apoorva

AU - Chow, Pierce Kah Hoe

PY - 2016/5/1

Y1 - 2016/5/1

N2 - An expert panel met to review the evidence for selective internal radiation therapy (SIRT) using yttrium-90 microspheres in hepatocellular carcinoma and metastases from colorectal cancer and neuroendocrine tumors. There is now convincing evidence for the safety and efficacy of SIRT in these situations albeit mostly from retrospective cohort studies. There are a number of ongoing prospective randomized controlled clinical trials investigating the role of SIRT in liver tumors; however, data from these trials are still several years away (although the SIRFLOX study has been recently published). In this evolving environment, published evidence and the authors' experience were used to summarize the current and potential role of SIRT in the management of hepatocellular carcinoma of intermediate or advanced stage and in liver-dominant metastatic colorectal cancer and metastatic neuroendocrine tumors.

AB - An expert panel met to review the evidence for selective internal radiation therapy (SIRT) using yttrium-90 microspheres in hepatocellular carcinoma and metastases from colorectal cancer and neuroendocrine tumors. There is now convincing evidence for the safety and efficacy of SIRT in these situations albeit mostly from retrospective cohort studies. There are a number of ongoing prospective randomized controlled clinical trials investigating the role of SIRT in liver tumors; however, data from these trials are still several years away (although the SIRFLOX study has been recently published). In this evolving environment, published evidence and the authors' experience were used to summarize the current and potential role of SIRT in the management of hepatocellular carcinoma of intermediate or advanced stage and in liver-dominant metastatic colorectal cancer and metastatic neuroendocrine tumors.

KW - liver cancer

KW - selective internal radiation

KW - transarterial chemoembolization

KW - yttrium 90 microspheres

UR - http://www.scopus.com/inward/record.url?scp=84965146573&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84965146573&partnerID=8YFLogxK

U2 - 10.2217/fon-2016-0035

DO - 10.2217/fon-2016-0035

M3 - Review article

C2 - 27007495

AN - SCOPUS:84965146573

SN - 1479-6694

VL - 12

SP - 1193

EP - 1204

JO - Future Oncology

JF - Future Oncology

IS - 9

ER -

Current role of selective internal radiation with yttrium-90 in liver tumors

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this