Current status of organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) exposure among mothers and their babies of Korea-CHECK cohort study

Sooran Choi; Hai joong Kim; Sunmi Kim; Gyuyeon Choi; Sungjoo Kim; Jeongim Park; Soon sup Shim; Inae Lee; Sungkyoon Kim; Hyo Bang Moon; Kyungho Choi; Jeong Jae Lee; Su Young Kim

doi:10.1016/j.scitotenv.2017.07.232

Current status of organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) exposure among mothers and their babies of Korea-CHECK cohort study

Sooran Choi, Hai joong Kim, Sunmi Kim, Gyuyeon Choi, Sungjoo Kim, Jeongim Park, Soon sup Shim, Inae Lee, Sungkyoon Kim, Hyo Bang Moon, Kyungho Choi, Jeong Jae Lee, Su Young Kim

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

Despite the global ban, organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) have been a persistent and significant environmental health issue worldwide. Prenatal exposure to these persistent organic pollutants (POPs) has been identified as a major route of exposure among developing fetuses and newborn infants. Among Children's Health and Environmental Health of Korea (CHECK) cohort population, pregnant females (n = 148) and their matching newborn infants (n = 117) recruited from four cities of Korea in 2011 were investigated. The blood serum and cord blood serum were sampled at delivery, and measured for 19 OCPs and 19 PCBs. In addition, a questionnaire regarding demographic characteristics, and dietary habits were conducted. The most frequently detected POPs in both maternal blood and cord blood were p,p′-dichlorodiphenyl dichloroethylene (DDE) (99% detection in maternal, and 98% in cord blood serum) and PCB153 (95% in maternal, 74% in cord blood serum). The levels of dichlorodiphenyl trichloroethanes (DDTs) in both maternal (average 82.5 ng/g lw) and cord blood serum (average 77.5 ng/g lw) were comparable to or greater than those reported in Japan about a decade ago. Approximately two thirds of the pregnant women and newborn infants showed the p,p′-DDE concentrations exceeding the biological equivalent (BE) corresponding to 10^{− 6} excess cancer risk. In addition, less chlorinated PCBs were detected higher in both maternal and cord serum. Less chlorinated PCBs also showed greater transplacental ratio. Dairy consumption among the subjects was positively associated, and tea consumption was negatively associated with serum levels of several POPs. Our results show that the exposure to legacy POPs, especially DDTs, among pregnant women and newborn infants is still prevailing, thus warrants measures for exposure mitigation among these vulnerable populations.

Original language	English
Pages (from-to)	674-681
Number of pages	8
Journal	Science of the Total Environment
Volume	618
DOIs	https://doi.org/10.1016/j.scitotenv.2017.07.232
Publication status	Published - 2018 Mar 15

Bibliographical note

Funding Information:
This work was supported by Ministry of Food and Drug Safety (MFDS, 11162MFDS722 ). The authors thank the participants of Children's Health and Environmental Chemicals of Korea (CHECK) Cohort and professor Byung Mu Lee, Sungkyunkwan University.

Funding Information:
This work was supported by Ministry of Food and Drug Safety (MFDS, 11162MFDS722). The authors thank the participants of Children's Health and Environmental Chemicals of Korea (CHECK) Cohort and professor Byung Mu Lee, Sungkyunkwan University.

Publisher Copyright:
© 2017

Keywords

Maternal blood
Organochlorine pesticides (OCPs)
Polychlorinated biphenyls (PCBs)
Umbilical cord blood

ASJC Scopus subject areas

Environmental Engineering
Environmental Chemistry
Waste Management and Disposal
Pollution

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.scitotenv.2017.07.232

Cite this

Choi, S., Kim, H. J., Kim, S., Choi, G., Kim, S., Park, J., Shim, S. S., Lee, I., Kim, S., Moon, H. B., Choi, K., Lee, J. J., & Kim, S. Y. (2018). Current status of organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) exposure among mothers and their babies of Korea-CHECK cohort study. Science of the Total Environment, 618, 674-681. https://doi.org/10.1016/j.scitotenv.2017.07.232

Choi, S, Kim, HJ, Kim, S, Choi, G, Kim, S, Park, J, Shim, SS, Lee, I, Kim, S, Moon, HB, Choi, K, Lee, JJ & Kim, SY 2018, 'Current status of organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) exposure among mothers and their babies of Korea-CHECK cohort study', Science of the Total Environment, vol. 618, pp. 674-681. https://doi.org/10.1016/j.scitotenv.2017.07.232

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abstract = "Despite the global ban, organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) have been a persistent and significant environmental health issue worldwide. Prenatal exposure to these persistent organic pollutants (POPs) has been identified as a major route of exposure among developing fetuses and newborn infants. Among Children's Health and Environmental Health of Korea (CHECK) cohort population, pregnant females (n = 148) and their matching newborn infants (n = 117) recruited from four cities of Korea in 2011 were investigated. The blood serum and cord blood serum were sampled at delivery, and measured for 19 OCPs and 19 PCBs. In addition, a questionnaire regarding demographic characteristics, and dietary habits were conducted. The most frequently detected POPs in both maternal blood and cord blood were p,p′-dichlorodiphenyl dichloroethylene (DDE) (99% detection in maternal, and 98% in cord blood serum) and PCB153 (95% in maternal, 74% in cord blood serum). The levels of dichlorodiphenyl trichloroethanes (DDTs) in both maternal (average 82.5 ng/g lw) and cord blood serum (average 77.5 ng/g lw) were comparable to or greater than those reported in Japan about a decade ago. Approximately two thirds of the pregnant women and newborn infants showed the p,p′-DDE concentrations exceeding the biological equivalent (BE) corresponding to 10− 6 excess cancer risk. In addition, less chlorinated PCBs were detected higher in both maternal and cord serum. Less chlorinated PCBs also showed greater transplacental ratio. Dairy consumption among the subjects was positively associated, and tea consumption was negatively associated with serum levels of several POPs. Our results show that the exposure to legacy POPs, especially DDTs, among pregnant women and newborn infants is still prevailing, thus warrants measures for exposure mitigation among these vulnerable populations.",

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author = "Sooran Choi and Kim, {Hai joong} and Sunmi Kim and Gyuyeon Choi and Sungjoo Kim and Jeongim Park and Shim, {Soon sup} and Inae Lee and Sungkyoon Kim and Moon, {Hyo Bang} and Kyungho Choi and Lee, {Jeong Jae} and Kim, {Su Young}",

note = "Funding Information: This work was supported by Ministry of Food and Drug Safety (MFDS, 11162MFDS722 ). The authors thank the participants of Children's Health and Environmental Chemicals of Korea (CHECK) Cohort and professor Byung Mu Lee, Sungkyunkwan University. Funding Information: This work was supported by Ministry of Food and Drug Safety (MFDS, 11162MFDS722). The authors thank the participants of Children's Health and Environmental Chemicals of Korea (CHECK) Cohort and professor Byung Mu Lee, Sungkyunkwan University. Publisher Copyright: {\textcopyright} 2017",

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AU - Choi, Sooran

AU - Kim, Hai joong

AU - Kim, Sunmi

AU - Choi, Gyuyeon

AU - Kim, Sungjoo

AU - Park, Jeongim

AU - Shim, Soon sup

AU - Lee, Inae

AU - Kim, Sungkyoon

AU - Moon, Hyo Bang

AU - Choi, Kyungho

AU - Lee, Jeong Jae

AU - Kim, Su Young

N1 - Funding Information: This work was supported by Ministry of Food and Drug Safety (MFDS, 11162MFDS722 ). The authors thank the participants of Children's Health and Environmental Chemicals of Korea (CHECK) Cohort and professor Byung Mu Lee, Sungkyunkwan University. Funding Information: This work was supported by Ministry of Food and Drug Safety (MFDS, 11162MFDS722). The authors thank the participants of Children's Health and Environmental Chemicals of Korea (CHECK) Cohort and professor Byung Mu Lee, Sungkyunkwan University. Publisher Copyright: © 2017

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N2 - Despite the global ban, organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) have been a persistent and significant environmental health issue worldwide. Prenatal exposure to these persistent organic pollutants (POPs) has been identified as a major route of exposure among developing fetuses and newborn infants. Among Children's Health and Environmental Health of Korea (CHECK) cohort population, pregnant females (n = 148) and their matching newborn infants (n = 117) recruited from four cities of Korea in 2011 were investigated. The blood serum and cord blood serum were sampled at delivery, and measured for 19 OCPs and 19 PCBs. In addition, a questionnaire regarding demographic characteristics, and dietary habits were conducted. The most frequently detected POPs in both maternal blood and cord blood were p,p′-dichlorodiphenyl dichloroethylene (DDE) (99% detection in maternal, and 98% in cord blood serum) and PCB153 (95% in maternal, 74% in cord blood serum). The levels of dichlorodiphenyl trichloroethanes (DDTs) in both maternal (average 82.5 ng/g lw) and cord blood serum (average 77.5 ng/g lw) were comparable to or greater than those reported in Japan about a decade ago. Approximately two thirds of the pregnant women and newborn infants showed the p,p′-DDE concentrations exceeding the biological equivalent (BE) corresponding to 10− 6 excess cancer risk. In addition, less chlorinated PCBs were detected higher in both maternal and cord serum. Less chlorinated PCBs also showed greater transplacental ratio. Dairy consumption among the subjects was positively associated, and tea consumption was negatively associated with serum levels of several POPs. Our results show that the exposure to legacy POPs, especially DDTs, among pregnant women and newborn infants is still prevailing, thus warrants measures for exposure mitigation among these vulnerable populations.

AB - Despite the global ban, organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) have been a persistent and significant environmental health issue worldwide. Prenatal exposure to these persistent organic pollutants (POPs) has been identified as a major route of exposure among developing fetuses and newborn infants. Among Children's Health and Environmental Health of Korea (CHECK) cohort population, pregnant females (n = 148) and their matching newborn infants (n = 117) recruited from four cities of Korea in 2011 were investigated. The blood serum and cord blood serum were sampled at delivery, and measured for 19 OCPs and 19 PCBs. In addition, a questionnaire regarding demographic characteristics, and dietary habits were conducted. The most frequently detected POPs in both maternal blood and cord blood were p,p′-dichlorodiphenyl dichloroethylene (DDE) (99% detection in maternal, and 98% in cord blood serum) and PCB153 (95% in maternal, 74% in cord blood serum). The levels of dichlorodiphenyl trichloroethanes (DDTs) in both maternal (average 82.5 ng/g lw) and cord blood serum (average 77.5 ng/g lw) were comparable to or greater than those reported in Japan about a decade ago. Approximately two thirds of the pregnant women and newborn infants showed the p,p′-DDE concentrations exceeding the biological equivalent (BE) corresponding to 10− 6 excess cancer risk. In addition, less chlorinated PCBs were detected higher in both maternal and cord serum. Less chlorinated PCBs also showed greater transplacental ratio. Dairy consumption among the subjects was positively associated, and tea consumption was negatively associated with serum levels of several POPs. Our results show that the exposure to legacy POPs, especially DDTs, among pregnant women and newborn infants is still prevailing, thus warrants measures for exposure mitigation among these vulnerable populations.

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KW - Organochlorine pesticides (OCPs)

KW - Polychlorinated biphenyls (PCBs)

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JO - Science of the Total Environment

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ER -

Current status of organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) exposure among mothers and their babies of Korea-CHECK cohort study

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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Cite this