Current Understanding of Stem Cell and Secretome Therapies in Liver Diseases

Dongkyu Kim, Gun Sik Cho, Choongseong Han, Dong Hyuk Park, Hee Kyung Park, Dong Hun Woo, Jong Hoon Kim

Research output: Contribution to journalReview articlepeer-review

11 Citations (Scopus)

Abstract

Liver failure is one of the main risks of death worldwide, and it originates from repetitive injuries and inflammations of liver tissues, which finally leads to the liver cirrhosis or cancer. Currently, liver transplantation is the only effective treatment for the liver diseases although it has a limitation due to donor scarcity. Alternatively, cell therapy to regenerate and reconstruct the damaged liver has been suggested to overcome the current limitation of liver disease cures. Several transplantable cell types could be utilized for recovering liver functions in injured liver, including bone marrow cells, mesenchymal stem cells, hematopoietic stem cells, macrophages, and stem cell-derived hepatocytes. Furthermore, paracrine effects of transplanted cells have been suggested as a new paradigm for liver disease cures, and this application would be a new strategy to cure liver failures. Therefore, here we reviewed the current status and challenges of therapy using stem cells for liver disease treatments.

Original languageEnglish
Pages (from-to)653-665
Number of pages13
JournalTissue Engineering and Regenerative Medicine
Volume14
Issue number6
DOIs
Publication statusPublished - 2017 Dec 1

Bibliographical note

Funding Information:
This research was supported by the Bio and Medical Technology Development Program of the NRF funded by the Korean government, MSIP (NRF-2017M3A9B4042581) and by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning (NRF-2017R1C1B2001891).

Publisher Copyright:
© 2017, The Korean Tissue Engineering and Regenerative Medicine Society and Springer Science+Business Media B.V.

Keywords

  • Liver failure
  • Liver regeneration
  • Secretome
  • Stem cell transplantation

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biomedical Engineering

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