Customized lipid-coated magnetic mesoporous silica nanoparticle doped with ceria nanoparticles for theragnosis of intracerebral hemorrhage

Bong Geun Cha, Han Gil Jeong, Dong Wan Kang, Myong Joo Nam, Chi Kyung Kim, Do Yeon Kim, In Young Choi, Seul Ki Ki, Song I. Kim, Ju hee Han, Jaeyun Kim, Seung Hoon Lee

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)


Intracerebral hemorrhage (ICH), caused by the sudden rupture of an artery within the brain, is a devastating subtype of stroke, which currently has no effective treatment. Intense inflammatory reactions that occur in the peri-hematomal area after ICH are more deleterious than the hematoma itself, resulting in subsequent brain edema and neurologic deterioration. Thus, we developed lipid-coated magnetic mesoporous silica nanoparticles doped with ceria nanoparticles (CeNPs), abbreviated as LMCs, which have both potent anti-inflammatory therapeutic effects via scavenging reactive oxygen species and help in increasing the efficacy of magnetic resonance imaging enhancement in the peri-hematomal area. LMCs consist of mesoporous silica nanoparticle-supported lipid bilayers, which are loaded with large amounts of CeNPs for scavenging of reactive oxygen species, and iron oxide nanoparticles for magnetic resonance imaging contrast. LMCs loaded with CeNPs exhibited strong anti-oxidative and anti-inflammatory activities in vitro. In the rodent ICH model, intracerebrally injected LMCs reached the peri-hematomal area and were engulfed by macrophages, which were clearly visualized by magnetic resonance imaging of the brain. Moreover, LMCs reduced inflammatory macrophage infiltration, and thus significantly reduced brain edema. Finally, LMC treatment markedly improved neurologic outcomes of the animals with ICH. Thus, LMC is the first nanobiomaterial that successfully showed theragnostic effects in ICH. [Figure not available: see fulltext.]

Original languageEnglish
Pages (from-to)3582-3592
Number of pages11
JournalNano Research
Issue number7
Publication statusPublished - 2018 Jul 1

Bibliographical note

Funding Information:
This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (No. HI17C0076), and also supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (No. NRF-2015R1A2A2A01007770).

Publisher Copyright:
© 2017, Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature.


  • ceria nanoparticles
  • imaging
  • intracerebral hemorrhage
  • magnetic mesoporous silica nanoparticle
  • reactive oxygen species
  • therapeutics

ASJC Scopus subject areas

  • Materials Science(all)
  • Electrical and Electronic Engineering


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