Cu2+-responsive bimodal (optical/MRI) contrast agent for cellular imaging

Joo Hee Jang, Sankarprasad Bhuniya, Jongeun Kang, Areum Yeom, Kwan Soo Hong, Jong Seung Kim

Research output: Contribution to journalArticlepeer-review

56 Citations (Scopus)


A water-soluble T1 magnetic resonance imaging contrast agent (1) has been synthesized. The bimodal contrast agent 1 responds to the Cu 2+ ion in living cells by enhancing the MRI modality signal whereas the optical signal gradually drops. This dual modality probe response depends on the cellular free copper ions in RAW 264.7 cells even at the micromolar level.

Original languageEnglish
Pages (from-to)4702-4705
Number of pages4
JournalOrganic Letters
Issue number18
Publication statusPublished - 2013 Sept 20

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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