Cu2+-responsive bimodal (optical/MRI) contrast agent for cellular imaging

Joo Hee Jang; Sankarprasad Bhuniya; Jongeun Kang; Areum Yeom; Kwan Soo Hong; Jong Seung Kim

doi:10.1021/ol4025293

Cu²⁺-responsive bimodal (optical/MRI) contrast agent for cellular imaging

Joo Hee Jang, Sankarprasad Bhuniya, Jongeun Kang, Areum Yeom, Kwan Soo Hong^*, Jong Seung Kim

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

61 Citations (Scopus)

Abstract

A water-soluble T₁ magnetic resonance imaging contrast agent (1) has been synthesized. The bimodal contrast agent 1 responds to the Cu ²⁺ ion in living cells by enhancing the MRI modality signal whereas the optical signal gradually drops. This dual modality probe response depends on the cellular free copper ions in RAW 264.7 cells even at the micromolar level.

Original language	English
Pages (from-to)	4702-4705
Number of pages	4
Journal	Organic Letters
Volume	15
Issue number	18
DOIs	https://doi.org/10.1021/ol4025293
Publication status	Published - 2013 Sept 20

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol4025293

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title = "Cu2+-responsive bimodal (optical/MRI) contrast agent for cellular imaging",

abstract = "A water-soluble T1 magnetic resonance imaging contrast agent (1) has been synthesized. The bimodal contrast agent 1 responds to the Cu 2+ ion in living cells by enhancing the MRI modality signal whereas the optical signal gradually drops. This dual modality probe response depends on the cellular free copper ions in RAW 264.7 cells even at the micromolar level.",

author = "Jang, \{Joo Hee\} and Sankarprasad Bhuniya and Jongeun Kang and Areum Yeom and Hong, \{Kwan Soo\} and Kim, \{Jong Seung\}",

year = "2013",

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T1 - Cu2+-responsive bimodal (optical/MRI) contrast agent for cellular imaging

AU - Jang, Joo Hee

AU - Bhuniya, Sankarprasad

AU - Kang, Jongeun

AU - Yeom, Areum

AU - Hong, Kwan Soo

AU - Kim, Jong Seung

PY - 2013/9/20

Y1 - 2013/9/20

N2 - A water-soluble T1 magnetic resonance imaging contrast agent (1) has been synthesized. The bimodal contrast agent 1 responds to the Cu 2+ ion in living cells by enhancing the MRI modality signal whereas the optical signal gradually drops. This dual modality probe response depends on the cellular free copper ions in RAW 264.7 cells even at the micromolar level.

AB - A water-soluble T1 magnetic resonance imaging contrast agent (1) has been synthesized. The bimodal contrast agent 1 responds to the Cu 2+ ion in living cells by enhancing the MRI modality signal whereas the optical signal gradually drops. This dual modality probe response depends on the cellular free copper ions in RAW 264.7 cells even at the micromolar level.

UR - https://www.scopus.com/pages/publications/84884561319

U2 - 10.1021/ol4025293

DO - 10.1021/ol4025293

M3 - Article

C2 - 24015763

AN - SCOPUS:84884561319

SN - 1523-7060

VL - 15

SP - 4702

EP - 4705

JO - Organic Letters

JF - Organic Letters

IS - 18

ER -

Cu²⁺-responsive bimodal (optical/MRI) contrast agent for cellular imaging

Abstract

ASJC Scopus subject areas

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