Cyanide as a powerful catalyst for facile preparation of 2-substituted benzoxazoles via aerobic oxidation

Yeon Ho Cho, Chun Young Lee, Deok Chan Ha, Cheol Hong Cheon

    Research output: Contribution to journalArticlepeer-review

    91 Citations (Scopus)

    Abstract

    A cyanide-catalyzed synthesis of 2-substituted benzoxazoles from Schiff bases via aerobic oxidation has been developed. The products from various Schiff bases were obtained in high yields in an open flask under ambient conditions without other external oxidants. We have also developed a simple one-step protocol for the synthesis of benzoxazoles from aminophenol and the corresponding aldehydes in the presence of cyanide without isolation of imine intermediates.

    Original languageEnglish
    Pages (from-to)2992-2996
    Number of pages5
    JournalAdvanced Synthesis and Catalysis
    Volume354
    Issue number16
    DOIs
    Publication statusPublished - 2012 Nov 12

    Keywords

    • aerobic oxidation
    • benzothiazoles
    • benzoxazoles
    • cyanide
    • one-pot protocol

    ASJC Scopus subject areas

    • Catalysis
    • Organic Chemistry

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