Cyanide as a powerful catalyst for facile preparation of 2-substituted benzoxazoles via aerobic oxidation

Yeon Ho Cho; Chun Young Lee; Deok Chan Ha; Cheol Hong Cheon

doi:10.1002/adsc.201200684

Cyanide as a powerful catalyst for facile preparation of 2-substituted benzoxazoles via aerobic oxidation

Yeon Ho Cho, Chun Young Lee, Deok Chan Ha, Cheol Hong Cheon

Research output: Contribution to journal › Article › peer-review

83 Citations (Scopus)

Abstract

A cyanide-catalyzed synthesis of 2-substituted benzoxazoles from Schiff bases via aerobic oxidation has been developed. The products from various Schiff bases were obtained in high yields in an open flask under ambient conditions without other external oxidants. We have also developed a simple one-step protocol for the synthesis of benzoxazoles from aminophenol and the corresponding aldehydes in the presence of cyanide without isolation of imine intermediates.

Original language	English
Pages (from-to)	2992-2996
Number of pages	5
Journal	Advanced Synthesis and Catalysis
Volume	354
Issue number	16
DOIs	https://doi.org/10.1002/adsc.201200684
Publication status	Published - 2012 Nov 12

Keywords

aerobic oxidation
benzothiazoles
benzoxazoles
cyanide
one-pot protocol

ASJC Scopus subject areas

Catalysis
Organic Chemistry

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10.1002/adsc.201200684

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abstract = "A cyanide-catalyzed synthesis of 2-substituted benzoxazoles from Schiff bases via aerobic oxidation has been developed. The products from various Schiff bases were obtained in high yields in an open flask under ambient conditions without other external oxidants. We have also developed a simple one-step protocol for the synthesis of benzoxazoles from aminophenol and the corresponding aldehydes in the presence of cyanide without isolation of imine intermediates.",

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AU - Cho, Yeon Ho

AU - Lee, Chun Young

AU - Ha, Deok Chan

AU - Cheon, Cheol Hong

PY - 2012/11/12

Y1 - 2012/11/12

N2 - A cyanide-catalyzed synthesis of 2-substituted benzoxazoles from Schiff bases via aerobic oxidation has been developed. The products from various Schiff bases were obtained in high yields in an open flask under ambient conditions without other external oxidants. We have also developed a simple one-step protocol for the synthesis of benzoxazoles from aminophenol and the corresponding aldehydes in the presence of cyanide without isolation of imine intermediates.

AB - A cyanide-catalyzed synthesis of 2-substituted benzoxazoles from Schiff bases via aerobic oxidation has been developed. The products from various Schiff bases were obtained in high yields in an open flask under ambient conditions without other external oxidants. We have also developed a simple one-step protocol for the synthesis of benzoxazoles from aminophenol and the corresponding aldehydes in the presence of cyanide without isolation of imine intermediates.

KW - aerobic oxidation

KW - benzothiazoles

KW - benzoxazoles

KW - cyanide

KW - one-pot protocol

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ER -

Cyanide as a powerful catalyst for facile preparation of 2-substituted benzoxazoles via aerobic oxidation

Abstract

Keywords

ASJC Scopus subject areas

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