Cybernetic modeling of the cephalosporin C fermentation process by Cephalosporium acremonium

Byung Min Kim; Seung Wook Kim; Dae Ryook Yang

doi:10.1023/A:1023080027754

Cybernetic modeling of the cephalosporin C fermentation process by Cephalosporium acremonium

Byung Min Kim
, Seung Wook Kim
, Dae Ryook Yang^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

A cybernetic mathematical model has been developed to describe the production of cephalosporin C. In developing the model, diauxic behavior of substrate consumption, morphological differentiation of cells, and catabolite repression of cephalosporin C production by the preferred substrate, glucose, were considered. The proposed model was tested on the experimental data from the literature and could adequately describe the morphological differentiation of cells, the sequential utilization of carbon sources and the production of cephalosporin C. It could be a useful tool to optimize the production of cephalosporin C by Cephalosporium acremonium in batch, fed-batch or continuous operations.

Original language	English
Pages (from-to)	611-616
Number of pages	6
Journal	Biotechnology Letters
Volume	25
Issue number	8
DOIs	https://doi.org/10.1023/A:1023080027754
Publication status	Published - 2003 Apr

Bibliographical note

Funding Information:
This study was financially supported by a Korea University Grant.

Keywords

Cephalosporin C
Cephalosporium acremonium
Cybernetic model
Diauxic growth
Morphological differentiation

ASJC Scopus subject areas

Biotechnology
Bioengineering
Applied Microbiology and Biotechnology

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title = "Cybernetic modeling of the cephalosporin C fermentation process by Cephalosporium acremonium",

abstract = "A cybernetic mathematical model has been developed to describe the production of cephalosporin C. In developing the model, diauxic behavior of substrate consumption, morphological differentiation of cells, and catabolite repression of cephalosporin C production by the preferred substrate, glucose, were considered. The proposed model was tested on the experimental data from the literature and could adequately describe the morphological differentiation of cells, the sequential utilization of carbon sources and the production of cephalosporin C. It could be a useful tool to optimize the production of cephalosporin C by Cephalosporium acremonium in batch, fed-batch or continuous operations.",

keywords = "Cephalosporin C, Cephalosporium acremonium, Cybernetic model, Diauxic growth, Morphological differentiation",

author = "Kim, \{Byung Min\} and Kim, \{Seung Wook\} and Yang, \{Dae Ryook\}",

note = "Funding Information: This study was financially supported by a Korea University Grant.",

year = "2003",

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doi = "10.1023/A:1023080027754",

language = "English",

volume = "25",

pages = "611--616",

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T1 - Cybernetic modeling of the cephalosporin C fermentation process by Cephalosporium acremonium

AU - Kim, Byung Min

AU - Kim, Seung Wook

AU - Yang, Dae Ryook

N1 - Funding Information: This study was financially supported by a Korea University Grant.

PY - 2003/4

Y1 - 2003/4

N2 - A cybernetic mathematical model has been developed to describe the production of cephalosporin C. In developing the model, diauxic behavior of substrate consumption, morphological differentiation of cells, and catabolite repression of cephalosporin C production by the preferred substrate, glucose, were considered. The proposed model was tested on the experimental data from the literature and could adequately describe the morphological differentiation of cells, the sequential utilization of carbon sources and the production of cephalosporin C. It could be a useful tool to optimize the production of cephalosporin C by Cephalosporium acremonium in batch, fed-batch or continuous operations.

AB - A cybernetic mathematical model has been developed to describe the production of cephalosporin C. In developing the model, diauxic behavior of substrate consumption, morphological differentiation of cells, and catabolite repression of cephalosporin C production by the preferred substrate, glucose, were considered. The proposed model was tested on the experimental data from the literature and could adequately describe the morphological differentiation of cells, the sequential utilization of carbon sources and the production of cephalosporin C. It could be a useful tool to optimize the production of cephalosporin C by Cephalosporium acremonium in batch, fed-batch or continuous operations.

KW - Cephalosporin C

KW - Cephalosporium acremonium

KW - Cybernetic model

KW - Diauxic growth

KW - Morphological differentiation

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M3 - Article

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AN - SCOPUS:0037697568

SN - 0141-5492

VL - 25

SP - 611

EP - 616

JO - Biotechnology Letters

JF - Biotechnology Letters

IS - 8

ER -

Cybernetic modeling of the cephalosporin C fermentation process by Cephalosporium acremonium

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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