Abstract
We investigated the expression of COX-1 and COX-2 in normal thyroid tissue, follicular adenoma and well-differentiated thyroid carcinomas and evaluated the difference in COX-1 and COX-2 expression. Ten normal thyroid tissues, ten follicular adenomas, ten papillary carcinomas and ten follicular carcinomas were analyzed by semiquantitative reverse transcriptase-polymerase chain reaction (RT-PCR) for expression of COX-1 and COX-2 mRNA. In addition, immunohistochemical staining was performed to find the expression of the two enzymes in normal thyroid tissues and thyroid neoplasia. Expression of COX-1 mRNA in the normal thyroid tissues, follicular adenomas and both well-differentiated carcinomas was similar and weak. However, COX-2 mRNA was strongly expressed in the well-differentiated carcinomas compared to those of normal thyroid tissue and follicular adenoma.
Original language | English |
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Pages (from-to) | 199-204 |
Number of pages | 6 |
Journal | European Archives of Oto-Rhino-Laryngology |
Volume | 263 |
Issue number | 3 |
DOIs | |
Publication status | Published - 2006 Mar |
Keywords
- Cyclooxygenase-1
- Cyclooxygenase-2
- Thyroid gland
ASJC Scopus subject areas
- Otorhinolaryngology