Cyclooxygenase 1 and 2 expressions in the human thyroid gland

Heung Man Lee; Seung Kuk Baek; Soon Young Kwon; Kwang-Yoon Jung; Sungwon Chae; Soon Jae Hwang; Jeong-Soo Woo; Juneyoung Lee

doi:10.1007/s00405-005-0999-x

Cyclooxygenase 1 and 2 expressions in the human thyroid gland

Heung Man Lee, Seung Kuk Baek, Soon Young Kwon, Kwang-Yoon Jung, Sungwon Chae, Soon Jae Hwang, Jeong-Soo Woo, Juneyoung Lee

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

We investigated the expression of COX-1 and COX-2 in normal thyroid tissue, follicular adenoma and well-differentiated thyroid carcinomas and evaluated the difference in COX-1 and COX-2 expression. Ten normal thyroid tissues, ten follicular adenomas, ten papillary carcinomas and ten follicular carcinomas were analyzed by semiquantitative reverse transcriptase-polymerase chain reaction (RT-PCR) for expression of COX-1 and COX-2 mRNA. In addition, immunohistochemical staining was performed to find the expression of the two enzymes in normal thyroid tissues and thyroid neoplasia. Expression of COX-1 mRNA in the normal thyroid tissues, follicular adenomas and both well-differentiated carcinomas was similar and weak. However, COX-2 mRNA was strongly expressed in the well-differentiated carcinomas compared to those of normal thyroid tissue and follicular adenoma.

Original language	English
Pages (from-to)	199-204
Number of pages	6
Journal	European Archives of Oto-Rhino-Laryngology
Volume	263
Issue number	3
DOIs	https://doi.org/10.1007/s00405-005-0999-x
Publication status	Published - 2006 Mar

Keywords

Cyclooxygenase-1
Cyclooxygenase-2
Thyroid gland

ASJC Scopus subject areas

Otorhinolaryngology

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10.1007/s00405-005-0999-x

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title = "Cyclooxygenase 1 and 2 expressions in the human thyroid gland",

abstract = "We investigated the expression of COX-1 and COX-2 in normal thyroid tissue, follicular adenoma and well-differentiated thyroid carcinomas and evaluated the difference in COX-1 and COX-2 expression. Ten normal thyroid tissues, ten follicular adenomas, ten papillary carcinomas and ten follicular carcinomas were analyzed by semiquantitative reverse transcriptase-polymerase chain reaction (RT-PCR) for expression of COX-1 and COX-2 mRNA. In addition, immunohistochemical staining was performed to find the expression of the two enzymes in normal thyroid tissues and thyroid neoplasia. Expression of COX-1 mRNA in the normal thyroid tissues, follicular adenomas and both well-differentiated carcinomas was similar and weak. However, COX-2 mRNA was strongly expressed in the well-differentiated carcinomas compared to those of normal thyroid tissue and follicular adenoma.",

keywords = "Cyclooxygenase-1, Cyclooxygenase-2, Thyroid gland",

author = "Lee, {Heung Man} and Baek, {Seung Kuk} and Kwon, {Soon Young} and Kwang-Yoon Jung and Sungwon Chae and Hwang, {Soon Jae} and Jeong-Soo Woo and Juneyoung Lee",

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doi = "10.1007/s00405-005-0999-x",

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AU - Lee, Heung Man

AU - Baek, Seung Kuk

AU - Kwon, Soon Young

AU - Jung, Kwang-Yoon

AU - Chae, Sungwon

AU - Hwang, Soon Jae

AU - Woo, Jeong-Soo

AU - Lee, Juneyoung

PY - 2006/3

Y1 - 2006/3

N2 - We investigated the expression of COX-1 and COX-2 in normal thyroid tissue, follicular adenoma and well-differentiated thyroid carcinomas and evaluated the difference in COX-1 and COX-2 expression. Ten normal thyroid tissues, ten follicular adenomas, ten papillary carcinomas and ten follicular carcinomas were analyzed by semiquantitative reverse transcriptase-polymerase chain reaction (RT-PCR) for expression of COX-1 and COX-2 mRNA. In addition, immunohistochemical staining was performed to find the expression of the two enzymes in normal thyroid tissues and thyroid neoplasia. Expression of COX-1 mRNA in the normal thyroid tissues, follicular adenomas and both well-differentiated carcinomas was similar and weak. However, COX-2 mRNA was strongly expressed in the well-differentiated carcinomas compared to those of normal thyroid tissue and follicular adenoma.

AB - We investigated the expression of COX-1 and COX-2 in normal thyroid tissue, follicular adenoma and well-differentiated thyroid carcinomas and evaluated the difference in COX-1 and COX-2 expression. Ten normal thyroid tissues, ten follicular adenomas, ten papillary carcinomas and ten follicular carcinomas were analyzed by semiquantitative reverse transcriptase-polymerase chain reaction (RT-PCR) for expression of COX-1 and COX-2 mRNA. In addition, immunohistochemical staining was performed to find the expression of the two enzymes in normal thyroid tissues and thyroid neoplasia. Expression of COX-1 mRNA in the normal thyroid tissues, follicular adenomas and both well-differentiated carcinomas was similar and weak. However, COX-2 mRNA was strongly expressed in the well-differentiated carcinomas compared to those of normal thyroid tissue and follicular adenoma.

KW - Cyclooxygenase-1

KW - Cyclooxygenase-2

KW - Thyroid gland

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ER -

Cyclooxygenase 1 and 2 expressions in the human thyroid gland

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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