Cytotoxic 6-alkylsalicylic acids from the endophytic Streptomyces laceyi

Nahyun Kim; Jin Chul Shin; Woncheol Kim; Bang Yeon Hwang; Beom Seok Kim; Young Soo Hong; Dongho Lee

doi:10.1038/ja.2006.105

Cytotoxic 6-alkylsalicylic acids from the endophytic Streptomyces laceyi

Nahyun Kim, Jin Chul Shin, Woncheol Kim, Bang Yeon Hwang, Beom Seok Kim, Young Soo Hong, Dongho Lee

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

Two new 6-alkylsalicylic acids, salaceyins A and B were isolated by bioassay-guided fractionation from the culture of the endophytic Streptomyces laceyi MS53 and their structures were determined on the basis of spectroscopic data. Salaceyins A and B exhibited modest cytotoxicity against a human breast cancer cell line (SKBR3) with IC₅₀ values of 3.0 and 5.5 μg/ml, respectively.

Original language	English
Pages (from-to)	797-800
Number of pages	4
Journal	Journal of Antibiotics
Volume	59
Issue number	12
DOIs	https://doi.org/10.1038/ja.2006.105
Publication status	Published - 2006 Dec

Bibliographical note

Funding Information:
Acknowledgements The work was supported by the 21C Frontier Microbial Genomics and Applications Center (MG05-0303-2-0 to Y.-S.H.), Ministry of Science and Technology, Republic of Korea and by the BioGreen21 Program (20050301034453 to B. S. Kim), Rural Development Administration, Republic of Korea. We thank the Korea Basic Science Institute for providing certain instruments used in this study.

Keywords

Alkysalicylic acid
Cytotoxic
Streptomyces

ASJC Scopus subject areas

Pharmacology
Drug Discovery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/ja.2006.105

Cite this

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title = "Cytotoxic 6-alkylsalicylic acids from the endophytic Streptomyces laceyi",

abstract = "Two new 6-alkylsalicylic acids, salaceyins A and B were isolated by bioassay-guided fractionation from the culture of the endophytic Streptomyces laceyi MS53 and their structures were determined on the basis of spectroscopic data. Salaceyins A and B exhibited modest cytotoxicity against a human breast cancer cell line (SKBR3) with IC50 values of 3.0 and 5.5 μg/ml, respectively.",

keywords = "Alkysalicylic acid, Cytotoxic, Streptomyces",

author = "Nahyun Kim and Shin, {Jin Chul} and Woncheol Kim and Hwang, {Bang Yeon} and Kim, {Beom Seok} and Hong, {Young Soo} and Dongho Lee",

note = "Funding Information: Acknowledgements The work was supported by the 21C Frontier Microbial Genomics and Applications Center (MG05-0303-2-0 to Y.-S.H.), Ministry of Science and Technology, Republic of Korea and by the BioGreen21 Program (20050301034453 to B. S. Kim), Rural Development Administration, Republic of Korea. We thank the Korea Basic Science Institute for providing certain instruments used in this study.",

year = "2006",

month = dec,

doi = "10.1038/ja.2006.105",

language = "English",

volume = "59",

pages = "797--800",

journal = "Journal of Antibiotics",

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AU - Kim, Nahyun

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AU - Kim, Woncheol

AU - Hwang, Bang Yeon

AU - Kim, Beom Seok

AU - Hong, Young Soo

AU - Lee, Dongho

N1 - Funding Information: Acknowledgements The work was supported by the 21C Frontier Microbial Genomics and Applications Center (MG05-0303-2-0 to Y.-S.H.), Ministry of Science and Technology, Republic of Korea and by the BioGreen21 Program (20050301034453 to B. S. Kim), Rural Development Administration, Republic of Korea. We thank the Korea Basic Science Institute for providing certain instruments used in this study.

PY - 2006/12

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N2 - Two new 6-alkylsalicylic acids, salaceyins A and B were isolated by bioassay-guided fractionation from the culture of the endophytic Streptomyces laceyi MS53 and their structures were determined on the basis of spectroscopic data. Salaceyins A and B exhibited modest cytotoxicity against a human breast cancer cell line (SKBR3) with IC50 values of 3.0 and 5.5 μg/ml, respectively.

AB - Two new 6-alkylsalicylic acids, salaceyins A and B were isolated by bioassay-guided fractionation from the culture of the endophytic Streptomyces laceyi MS53 and their structures were determined on the basis of spectroscopic data. Salaceyins A and B exhibited modest cytotoxicity against a human breast cancer cell line (SKBR3) with IC50 values of 3.0 and 5.5 μg/ml, respectively.

KW - Alkysalicylic acid

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DO - 10.1038/ja.2006.105

M3 - Article

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SN - 0021-8820

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SP - 797

EP - 800

JO - Journal of Antibiotics

JF - Journal of Antibiotics

IS - 12

ER -

Cytotoxic 6-alkylsalicylic acids from the endophytic Streptomyces laceyi

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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