Abstract
Two new 6-alkylsalicylic acids, salaceyins A and B were isolated by bioassay-guided fractionation from the culture of the endophytic Streptomyces laceyi MS53 and their structures were determined on the basis of spectroscopic data. Salaceyins A and B exhibited modest cytotoxicity against a human breast cancer cell line (SKBR3) with IC50 values of 3.0 and 5.5 μg/ml, respectively.
Original language | English |
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Pages (from-to) | 797-800 |
Number of pages | 4 |
Journal | Journal of Antibiotics |
Volume | 59 |
Issue number | 12 |
DOIs | |
Publication status | Published - 2006 Dec |
Bibliographical note
Funding Information:Acknowledgements The work was supported by the 21C Frontier Microbial Genomics and Applications Center (MG05-0303-2-0 to Y.-S.H.), Ministry of Science and Technology, Republic of Korea and by the BioGreen21 Program (20050301034453 to B. S. Kim), Rural Development Administration, Republic of Korea. We thank the Korea Basic Science Institute for providing certain instruments used in this study.
Keywords
- Alkysalicylic acid
- Cytotoxic
- Streptomyces
ASJC Scopus subject areas
- Pharmacology
- Drug Discovery