Cytotoxic diterpenoids as potential anticancer agents from the twigs of Casearia kurzii

Feng Liu; Qi Zhang; Xueyuan Yang; Yaru Xi; Xuke Zhang; Huimei Wang; Jie Zhang; Muhetaer Tuerhong; Da Qing Jin; Dongho Lee; Jing Xu; Yasushi Ohizumi; Ling Shuai; Yuanqiang Guo

doi:10.1016/j.bioorg.2019.102995

Cytotoxic diterpenoids as potential anticancer agents from the twigs of Casearia kurzii

Feng Liu, Qi Zhang, Xueyuan Yang, Yaru Xi, Xuke Zhang, Huimei Wang, Jie Zhang, Muhetaer Tuerhong, Da Qing Jin, Dongho Lee, Jing Xu, Yasushi Ohizumi, Ling Shuai, Yuanqiang Guo

Department of Biosystems and Biotechnology

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

A search for bioactive natural products as anticancer lead compounds has led to the isolation of five new clerodane diterpenoids (1–5) from the twigs of Casearia kurzii. Their structures were elucidated by extensive analysis of their NMR, IR, and HRESIMS data, and the absolute configurations were determined by experimental and calculated electronic circular dichroism (ECD) data analysis. The isolates were biologically evaluated and showed cytotoxic activities toward human lung cancer cells (A549), human cervical cancer cells (HeLa), and human hepatocellular carcinoma cells (HepG2). The most active compound (5) with an IC₅₀ value of 5.3 μM against HeLa cells, was found to induce apoptosis and arrest the HeLa cell cycle at G0/G1 stage to exert cytotoxic effects.

Original language	English
Article number	102995
Journal	Bioorganic Chemistry
Volume	89
DOIs	https://doi.org/10.1016/j.bioorg.2019.102995
Publication status	Published - 2019 Aug

Keywords

Apoptosis
Casearia kurzii
Cell cycle
Clerodane diterpenoids
Cytotoxic activities

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Drug Discovery
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bioorg.2019.102995

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@article{c9f2358811764cbfaa3ca3b72fece464,

title = "Cytotoxic diterpenoids as potential anticancer agents from the twigs of Casearia kurzii",

abstract = "A search for bioactive natural products as anticancer lead compounds has led to the isolation of five new clerodane diterpenoids (1–5) from the twigs of Casearia kurzii. Their structures were elucidated by extensive analysis of their NMR, IR, and HRESIMS data, and the absolute configurations were determined by experimental and calculated electronic circular dichroism (ECD) data analysis. The isolates were biologically evaluated and showed cytotoxic activities toward human lung cancer cells (A549), human cervical cancer cells (HeLa), and human hepatocellular carcinoma cells (HepG2). The most active compound (5) with an IC50 value of 5.3 μM against HeLa cells, was found to induce apoptosis and arrest the HeLa cell cycle at G0/G1 stage to exert cytotoxic effects.",

keywords = "Apoptosis, Casearia kurzii, Cell cycle, Clerodane diterpenoids, Cytotoxic activities",

author = "Feng Liu and Qi Zhang and Xueyuan Yang and Yaru Xi and Xuke Zhang and Huimei Wang and Jie Zhang and Muhetaer Tuerhong and Jin, {Da Qing} and Dongho Lee and Jing Xu and Yasushi Ohizumi and Ling Shuai and Yuanqiang Guo",

note = "Funding Information: This work was supported by the National Key Research and Development Program of China (No. 2018YFA0507204), the National Natural Science Foundation of China (Nos. U1703107 and U1801288), Hundred Young Academic Leaders Program of Nankai University, State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University, No. CMEMR2019-B01), and the Fundamental Research Funds for the Central Universities (Nos. 63191142 and 63191731). Funding Information: This work was supported by the National Key Research and Development Program of China (No. 2018YFA0507204 ), the National Natural Science Foundation of China (Nos. U1703107 and U1801288 ), Hundred Young Academic Leaders Program of Nankai University, State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University, No. CMEMR2019-B01), and the Fundamental Research Funds for the Central Universities (Nos. 63191142 and 63191731 ). Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

month = aug,

doi = "10.1016/j.bioorg.2019.102995",

language = "English",

volume = "89",

journal = "Bioorganic Chemistry",

issn = "0045-2068",

publisher = "Academic Press Inc.",

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T1 - Cytotoxic diterpenoids as potential anticancer agents from the twigs of Casearia kurzii

AU - Liu, Feng

AU - Zhang, Qi

AU - Yang, Xueyuan

AU - Xi, Yaru

AU - Zhang, Xuke

AU - Wang, Huimei

AU - Zhang, Jie

AU - Tuerhong, Muhetaer

AU - Jin, Da Qing

AU - Lee, Dongho

AU - Xu, Jing

AU - Ohizumi, Yasushi

AU - Shuai, Ling

AU - Guo, Yuanqiang

N1 - Funding Information: This work was supported by the National Key Research and Development Program of China (No. 2018YFA0507204), the National Natural Science Foundation of China (Nos. U1703107 and U1801288), Hundred Young Academic Leaders Program of Nankai University, State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University, No. CMEMR2019-B01), and the Fundamental Research Funds for the Central Universities (Nos. 63191142 and 63191731). Funding Information: This work was supported by the National Key Research and Development Program of China (No. 2018YFA0507204 ), the National Natural Science Foundation of China (Nos. U1703107 and U1801288 ), Hundred Young Academic Leaders Program of Nankai University, State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University, No. CMEMR2019-B01), and the Fundamental Research Funds for the Central Universities (Nos. 63191142 and 63191731 ). Publisher Copyright: © 2019 Elsevier Inc.

PY - 2019/8

Y1 - 2019/8

N2 - A search for bioactive natural products as anticancer lead compounds has led to the isolation of five new clerodane diterpenoids (1–5) from the twigs of Casearia kurzii. Their structures were elucidated by extensive analysis of their NMR, IR, and HRESIMS data, and the absolute configurations were determined by experimental and calculated electronic circular dichroism (ECD) data analysis. The isolates were biologically evaluated and showed cytotoxic activities toward human lung cancer cells (A549), human cervical cancer cells (HeLa), and human hepatocellular carcinoma cells (HepG2). The most active compound (5) with an IC50 value of 5.3 μM against HeLa cells, was found to induce apoptosis and arrest the HeLa cell cycle at G0/G1 stage to exert cytotoxic effects.

AB - A search for bioactive natural products as anticancer lead compounds has led to the isolation of five new clerodane diterpenoids (1–5) from the twigs of Casearia kurzii. Their structures were elucidated by extensive analysis of their NMR, IR, and HRESIMS data, and the absolute configurations were determined by experimental and calculated electronic circular dichroism (ECD) data analysis. The isolates were biologically evaluated and showed cytotoxic activities toward human lung cancer cells (A549), human cervical cancer cells (HeLa), and human hepatocellular carcinoma cells (HepG2). The most active compound (5) with an IC50 value of 5.3 μM against HeLa cells, was found to induce apoptosis and arrest the HeLa cell cycle at G0/G1 stage to exert cytotoxic effects.

KW - Apoptosis

KW - Casearia kurzii

KW - Cell cycle

KW - Clerodane diterpenoids

KW - Cytotoxic activities

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DO - 10.1016/j.bioorg.2019.102995

M3 - Article

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SN - 0045-2068

VL - 89

JO - Bioorganic Chemistry

JF - Bioorganic Chemistry

M1 - 102995

ER -

Cytotoxic diterpenoids as potential anticancer agents from the twigs of Casearia kurzii

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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