Cytotoxic Drimane Sesquiterpenoids Isolated from Perenniporia maackiae

Jaeyoung Kwon; Hyaemin Lee; Young Hye Seo; Jieun Yun; Jun Lee; Hak Cheol Kwon; Yuanqiang Guo; Jong Soon Kang; Jae Jin Kim; Dongho Lee

doi:10.1021/acs.jnatprod.8b00175

Cytotoxic Drimane Sesquiterpenoids Isolated from Perenniporia maackiae

Jaeyoung Kwon
, Hyaemin Lee
, Young Hye Seo
, Jieun Yun
, Jun Lee
, Hak Cheol Kwon
, Yuanqiang Guo
, Jong Soon Kang
, Jae Jin Kim
, Dongho Lee^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

A chemical investigation of a basidiomycetes fungus, Perenniporia maackiae, led to the discovery of 12 drimane sesquiterpenoids, including seven new constituents (1-7). The elucidation of the structures was performed via interpreting extensive spectroscopic methods, including ECD calculations. Among all isolated compounds, 1, 2, and 6 exhibited cytotoxicity toward six carcinoma cells, including ACHN, HCT-15, MDA-MB-231, NCI-H23, NUGC-3, and PC-3 cells, with half-maximal inhibition of cell proliferation values of 1.2-6.0 μM.

Original language	English
Pages (from-to)	1444-1450
Number of pages	7
Journal	Journal of Natural Products
Volume	81
Issue number	6
DOIs	https://doi.org/10.1021/acs.jnatprod.8b00175
Publication status	Published - 2018 Jun 22

Bibliographical note

Publisher Copyright:
© 2018 American Chemical Society and American Society of Pharmacognosy.

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/acs.jnatprod.8b00175

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title = "Cytotoxic Drimane Sesquiterpenoids Isolated from Perenniporia maackiae",

abstract = "A chemical investigation of a basidiomycetes fungus, Perenniporia maackiae, led to the discovery of 12 drimane sesquiterpenoids, including seven new constituents (1-7). The elucidation of the structures was performed via interpreting extensive spectroscopic methods, including ECD calculations. Among all isolated compounds, 1, 2, and 6 exhibited cytotoxicity toward six carcinoma cells, including ACHN, HCT-15, MDA-MB-231, NCI-H23, NUGC-3, and PC-3 cells, with half-maximal inhibition of cell proliferation values of 1.2-6.0 μM.",

author = "Jaeyoung Kwon and Hyaemin Lee and Seo, \{Young Hye\} and Jieun Yun and Jun Lee and Kwon, \{Hak Cheol\} and Yuanqiang Guo and Kang, \{Jong Soon\} and Kim, \{Jae Jin\} and Dongho Lee",

note = "Publisher Copyright: {\textcopyright} 2018 American Chemical Society and American Society of Pharmacognosy.",

year = "2018",

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doi = "10.1021/acs.jnatprod.8b00175",

language = "English",

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AU - Kwon, Jaeyoung

AU - Lee, Hyaemin

AU - Seo, Young Hye

AU - Yun, Jieun

AU - Lee, Jun

AU - Kwon, Hak Cheol

AU - Guo, Yuanqiang

AU - Kang, Jong Soon

AU - Kim, Jae Jin

AU - Lee, Dongho

PY - 2018/6/22

Y1 - 2018/6/22

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AB - A chemical investigation of a basidiomycetes fungus, Perenniporia maackiae, led to the discovery of 12 drimane sesquiterpenoids, including seven new constituents (1-7). The elucidation of the structures was performed via interpreting extensive spectroscopic methods, including ECD calculations. Among all isolated compounds, 1, 2, and 6 exhibited cytotoxicity toward six carcinoma cells, including ACHN, HCT-15, MDA-MB-231, NCI-H23, NUGC-3, and PC-3 cells, with half-maximal inhibition of cell proliferation values of 1.2-6.0 μM.

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SP - 1444

EP - 1450

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 6

ER -

Cytotoxic Drimane Sesquiterpenoids Isolated from Perenniporia maackiae

Abstract

Bibliographical note

ASJC Scopus subject areas

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