Abstract
Purpose: The aim of this study was to assess the proper timing of extradural cortical stimulation (ECS) on the motor relearning in a rat model of subacute photothrombotic stroke. Methods: Photothrombotic infarction was induced on the dominant sensorimotor cortex in male Sprague-Dawley rats after training in a single-pellet reaching task (SPRT). Rats were randomly divided into three groups after stroke: ECS during the inactive period (Day-ECS group), ECS during the active period (Night-ECS group) and no ECS (Non-stimulated group). Six sham-operated rats were assigned to the control group. The Day- and Night-ECS group received continuous ECS for 12 hours during the day or night for 2 weeks from day 4 after the stroke. Behavioral assessment with SPRT was performed daily. Results: SPRT showed a significantly faster and greater improvement in the Day and Night-ECS groups than in the Non-stimulated group. In the Day- and Night-ECS groups, the success rate of SPRT differed significantly from Non-stimulated group on day 11 and day 8, respectively. In addition, the Night-ECS group showed a significantly higher SPRT success rate than the Day-ECS group from days 10 to 13. Conclusion: ECS during the active period might be more effective for motor relearning in the subacute stroke rat model.
| Original language | English |
|---|---|
| Pages (from-to) | 379-387 |
| Number of pages | 9 |
| Journal | Restorative Neurology and Neuroscience |
| Volume | 34 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2016 Jun 14 |
Keywords
- Day/night
- electrical stimulation
- extradural cortical stimulation
- motor learning
- motor recovery
- stroke
ASJC Scopus subject areas
- Neurology
- Developmental Neuroscience
- Clinical Neurology