Deconstructing poloxamer and poloxamine block copolymers to access poly(ethylene glycol) and poly(propylene oxide)-based thermoresponsive polymers

Jeonghui Hong; Junki Oh; Anzar Khan

doi:10.1080/10601325.2020.1724055

Deconstructing poloxamer and poloxamine block copolymers to access poly(ethylene glycol) and poly(propylene oxide)-based thermoresponsive polymers

Jeonghui Hong, Junki Oh, Anzar Khan

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Poloxamer (Pluronic^®) and poloxamine (Tetronic^®) are commercially important block copolymers composed of polypropylene oxide (PPO) and polyethylene glycol (PEG) segments. Due to the difference in chemical polarity of the two blocks, the copolymers exhibit amphiphilicity and thermally induced aggregation behavior in aqueous solutions. The present work shows that block copolymer architecture is not necessary to achieve an amphiphilic character in PPO and PEG-based polymers. Instead a simple molecular tweaking by adding a very short hydrophilic or hydrophobic side-chain allows for attaining amphiphilicity and consequential thermoresponsiveness in PEG and PPO-rich polymers.

Original language	English
Pages (from-to)	472-478
Number of pages	7
Journal	Journal of Macromolecular Science, Part A: Pure and Applied Chemistry
Volume	57
Issue number	6
DOIs	https://doi.org/10.1080/10601325.2020.1724055
Publication status	Published - 2020 Jun 2

Bibliographical note

Funding Information:
This research was funded by National Research Foundation of Korea grant funded by the Korean government (MSIP) (NRF-18R1D1A1B07048527).

Publisher Copyright:
© 2020, © 2020 Taylor & Francis Group, LLC.

Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.

Keywords

Amine-epoxy reaction
amphiphilic polymers
poly(ß-hydroxyl amine)s
thermoresponsive polymers
“click” polymerization

ASJC Scopus subject areas

Ceramics and Composites
General Chemistry
Polymers and Plastics
Materials Chemistry

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10.1080/10601325.2020.1724055

Cite this

Deconstructing poloxamer and poloxamine block copolymers to access poly(ethylene glycol) and poly(propylene oxide)-based thermoresponsive polymers. / Hong, Jeonghui; Oh, Junki; Khan, Anzar.
In: Journal of Macromolecular Science, Part A: Pure and Applied Chemistry, Vol. 57, No. 6, 02.06.2020, p. 472-478.

Research output: Contribution to journal › Article › peer-review

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title = "Deconstructing poloxamer and poloxamine block copolymers to access poly(ethylene glycol) and poly(propylene oxide)-based thermoresponsive polymers",

abstract = "Poloxamer (Pluronic{\textregistered}) and poloxamine (Tetronic{\textregistered}) are commercially important block copolymers composed of polypropylene oxide (PPO) and polyethylene glycol (PEG) segments. Due to the difference in chemical polarity of the two blocks, the copolymers exhibit amphiphilicity and thermally induced aggregation behavior in aqueous solutions. The present work shows that block copolymer architecture is not necessary to achieve an amphiphilic character in PPO and PEG-based polymers. Instead a simple molecular tweaking by adding a very short hydrophilic or hydrophobic side-chain allows for attaining amphiphilicity and consequential thermoresponsiveness in PEG and PPO-rich polymers.",

keywords = "Amine-epoxy reaction, amphiphilic polymers, poly({\ss}-hydroxyl amine)s, thermoresponsive polymers, “click” polymerization",

author = "Jeonghui Hong and Junki Oh and Anzar Khan",

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AU - Oh, Junki

AU - Khan, Anzar

N1 - Funding Information: This research was funded by National Research Foundation of Korea grant funded by the Korean government (MSIP) (NRF-18R1D1A1B07048527). Publisher Copyright: © 2020, © 2020 Taylor & Francis Group, LLC. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

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N2 - Poloxamer (Pluronic®) and poloxamine (Tetronic®) are commercially important block copolymers composed of polypropylene oxide (PPO) and polyethylene glycol (PEG) segments. Due to the difference in chemical polarity of the two blocks, the copolymers exhibit amphiphilicity and thermally induced aggregation behavior in aqueous solutions. The present work shows that block copolymer architecture is not necessary to achieve an amphiphilic character in PPO and PEG-based polymers. Instead a simple molecular tweaking by adding a very short hydrophilic or hydrophobic side-chain allows for attaining amphiphilicity and consequential thermoresponsiveness in PEG and PPO-rich polymers.

AB - Poloxamer (Pluronic®) and poloxamine (Tetronic®) are commercially important block copolymers composed of polypropylene oxide (PPO) and polyethylene glycol (PEG) segments. Due to the difference in chemical polarity of the two blocks, the copolymers exhibit amphiphilicity and thermally induced aggregation behavior in aqueous solutions. The present work shows that block copolymer architecture is not necessary to achieve an amphiphilic character in PPO and PEG-based polymers. Instead a simple molecular tweaking by adding a very short hydrophilic or hydrophobic side-chain allows for attaining amphiphilicity and consequential thermoresponsiveness in PEG and PPO-rich polymers.

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Deconstructing poloxamer and poloxamine block copolymers to access poly(ethylene glycol) and poly(propylene oxide)-based thermoresponsive polymers

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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