TY - JOUR
T1 - Deconstructing poloxamer and poloxamine block copolymers to access poly(ethylene glycol) and poly(propylene oxide)-based thermoresponsive polymers
AU - Hong, Jeonghui
AU - Oh, Junki
AU - Khan, Anzar
N1 - Funding Information:
This research was funded by National Research Foundation of Korea grant funded by the Korean government (MSIP) (NRF-18R1D1A1B07048527).
Publisher Copyright:
© 2020, © 2020 Taylor & Francis Group, LLC.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/6/2
Y1 - 2020/6/2
N2 - Poloxamer (Pluronic®) and poloxamine (Tetronic®) are commercially important block copolymers composed of polypropylene oxide (PPO) and polyethylene glycol (PEG) segments. Due to the difference in chemical polarity of the two blocks, the copolymers exhibit amphiphilicity and thermally induced aggregation behavior in aqueous solutions. The present work shows that block copolymer architecture is not necessary to achieve an amphiphilic character in PPO and PEG-based polymers. Instead a simple molecular tweaking by adding a very short hydrophilic or hydrophobic side-chain allows for attaining amphiphilicity and consequential thermoresponsiveness in PEG and PPO-rich polymers.
AB - Poloxamer (Pluronic®) and poloxamine (Tetronic®) are commercially important block copolymers composed of polypropylene oxide (PPO) and polyethylene glycol (PEG) segments. Due to the difference in chemical polarity of the two blocks, the copolymers exhibit amphiphilicity and thermally induced aggregation behavior in aqueous solutions. The present work shows that block copolymer architecture is not necessary to achieve an amphiphilic character in PPO and PEG-based polymers. Instead a simple molecular tweaking by adding a very short hydrophilic or hydrophobic side-chain allows for attaining amphiphilicity and consequential thermoresponsiveness in PEG and PPO-rich polymers.
KW - Amine-epoxy reaction
KW - amphiphilic polymers
KW - poly(ß-hydroxyl amine)s
KW - thermoresponsive polymers
KW - “click” polymerization
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U2 - 10.1080/10601325.2020.1724055
DO - 10.1080/10601325.2020.1724055
M3 - Article
AN - SCOPUS:85079213484
SN - 1060-1325
VL - 57
SP - 472
EP - 478
JO - Journal of Macromolecular Science, Part A: Pure and Applied Chemistry
JF - Journal of Macromolecular Science, Part A: Pure and Applied Chemistry
IS - 6
ER -