TY - JOUR
T1 - Decrease in plasma adiponectin concentrations in patients with vasospastic angina
AU - Hong, Soon Jun
AU - Park, Chang Gyu
AU - Seo, Hong Seog
AU - Rha, Seung Woon
AU - Kim, Jin Won
AU - Oh, Dong Joo
AU - Kwon, Jung Ah
AU - Lee, Kap No
AU - Jang, Yang Soo
AU - Ro, Young Moo
PY - 2006/4
Y1 - 2006/4
N2 - Background and Objectives: Plasma adiponectin, which decreases the progression of atherosclerosis and insulin resistance, as well as suppressing lipid accumulation in macrophages, is decreased in patients with acute myocardial infarction and unstable angina pectoris; however, the correlation between plasma adiponectin and vasospastic angina pectoris (VAP) remains to be verified. We compared the plasma adiponectin concentration between patients with VAP and other coronary artery diseases; moreover, we investigated the association between the plasma adiponectin concentration and VAP. Subjects and Methods: Following coronary angiography for the evaluation of chest pain, 395 subjects (180 women and 215 men) were divided into 4 groups: acute coronary syndrome (ACS)(n=117), VAP (n=94), stable angina pectoris (SAP)(n=108) and angiographically normal coronary artery (n=76). The acetylcholine provocation test was used to confirm VAP, and plasma adiponectin concentrations were measured in all participants. Results: The plasma adiponectin concentrations in patients with VAP and ACS were significantly lower than that of the normal coronary artery group (6.6 ± 5.4 vs. 5.2 ± 4.0 vs. 9.0 ± 6.2 μg/mL, p<0.001, respectively). A multivariate analysis indicated that plasma adiponectin [odd ratio (OR) 0.744, 95% confidence interval (CI) 0.645 to 0.858, p=0.001], smoking (OR 2.054, 95% CI 1.027 to 4.106, p=0.042) and age (OR 0.966, 95% CI 0.935 to 0.997, p=0.031) were independently correlated in patients diagnosed with VAP. Conclusion: Our results suggest that a decreased plasma adiponectin concentration may be associated with VAP.
AB - Background and Objectives: Plasma adiponectin, which decreases the progression of atherosclerosis and insulin resistance, as well as suppressing lipid accumulation in macrophages, is decreased in patients with acute myocardial infarction and unstable angina pectoris; however, the correlation between plasma adiponectin and vasospastic angina pectoris (VAP) remains to be verified. We compared the plasma adiponectin concentration between patients with VAP and other coronary artery diseases; moreover, we investigated the association between the plasma adiponectin concentration and VAP. Subjects and Methods: Following coronary angiography for the evaluation of chest pain, 395 subjects (180 women and 215 men) were divided into 4 groups: acute coronary syndrome (ACS)(n=117), VAP (n=94), stable angina pectoris (SAP)(n=108) and angiographically normal coronary artery (n=76). The acetylcholine provocation test was used to confirm VAP, and plasma adiponectin concentrations were measured in all participants. Results: The plasma adiponectin concentrations in patients with VAP and ACS were significantly lower than that of the normal coronary artery group (6.6 ± 5.4 vs. 5.2 ± 4.0 vs. 9.0 ± 6.2 μg/mL, p<0.001, respectively). A multivariate analysis indicated that plasma adiponectin [odd ratio (OR) 0.744, 95% confidence interval (CI) 0.645 to 0.858, p=0.001], smoking (OR 2.054, 95% CI 1.027 to 4.106, p=0.042) and age (OR 0.966, 95% CI 0.935 to 0.997, p=0.031) were independently correlated in patients diagnosed with VAP. Conclusion: Our results suggest that a decreased plasma adiponectin concentration may be associated with VAP.
KW - Acetylcholine
KW - Adiponectin
KW - Coronary artery vasospasm
UR - http://www.scopus.com/inward/record.url?scp=33646486621&partnerID=8YFLogxK
U2 - 10.4070/kcj.2006.36.4.255
DO - 10.4070/kcj.2006.36.4.255
M3 - Article
AN - SCOPUS:33646486621
SN - 1738-5520
VL - 36
SP - 255
EP - 260
JO - Korean Circulation Journal
JF - Korean Circulation Journal
IS - 4
ER -