Decreased serum club cell secretory protein in asthma and chronic obstructive pulmonary disease overlap: A pilot study

Jee Youn Oh, Young Seok Lee, Kyung Hoon Min, Gyu Young Hur, Sung Yong Lee, Kyung Ho Kang, Chin Kook Rhee, Seoung Ju Park, Jae Jeong Shim

    Research output: Contribution to journalArticlepeer-review

    13 Citations (Scopus)


    Purpose: Improvement in the diagnosis of asthma and chronic obstructive pulmonary disease (COPD) overlap (ACO), and identification of biomarkers for phenotype recognition will encourage good patient care by providing optimal therapy. We investigated club cell secretory protein (CC-16), a protective and anti-inflammatory mediator, as a new candidate biomarker for diagnosing ACO. Patients and methods: We performed a multicenter cohort study. A total of 107 patients were divided into three groups - asthma, COPD, and ACO - according to the Spanish guidelines algorithm, and enrolled into the study. Serum CC-16 levels were measured using commercial ELISA kits. Results: Serum CC-16 levels were the lowest in patients with ACO. Low serum CC-16 levels were a significant marker for the ACO even after adjustment for age, sex, and smoking intensity. Serum CC-16 levels were positively correlated with forced expiratory volume in 1 second (FEV 1 ), forced vital capacity (FVC), forced expiratory flow at 25%-75% of FVC, FEV 1 /FVC, vital capacity, and diffusing capacity of the lung for carbon monoxide, and were negatively correlated with smoking amount (pack-years), bronchodilator response, fractional residual capacity, residual volume, and number of exacerbations per year. FEV 1 and serum CC-16 levels were significantly lower in patients with frequent exacerbations. Conclusion: Serum CC-16 has the potential to be a biomarker for ACO diagnosis and also treat frequent exacerbations in patients with chronic inflammatory airway diseases.

    Original languageEnglish
    Pages (from-to)3411-3417
    Number of pages7
    JournalInternational Journal of COPD
    Publication statusPublished - 2018

    Bibliographical note

    Publisher Copyright:
    © 2018 Oh et al.


    • ACO
    • Asthma
    • COPD
    • Club cell secretory protein-16
    • Exacerbation
    • Smoking

    ASJC Scopus subject areas

    • Pulmonary and Respiratory Medicine
    • Health Policy
    • Public Health, Environmental and Occupational Health


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