Abstract
Background: Numerous reports suggest that the overexpression of STAT3 in keratinocytes is associated with the induction of pruritus. However, the effect of decreased STAT3 expression remains unknown. Objective: RNA sequencing data were obtained using two groups of human-derived keratinocytes (HaCaTs): wild type and STAT3 knockdown. Genes were clustered according to established criteria and analyzed using Gene Ontology, KEGG, and STRING analyses. Results: Changes were observed in a total of 239 genes, including 133 overexpressed and 106 underexpressed genes in the STAT3 knockdown group. Among downregulated biological processes, the formation of cell-to-cell junctions is possibly significant. Conclusion: Reduced STAT3 expression in keratinocytes may impair cell-to-cell junction formation, potentially contributing to skin barrier dysfunction and pruritus. However, further experimental validation is needed to establish this relationship.
| Original language | English |
|---|---|
| Journal | Molecular and Cellular Toxicology |
| DOIs | |
| Publication status | Accepted/In press - 2025 |
Bibliographical note
Publisher Copyright:© The Author(s) under exclusive licence to The Korean Society of Toxicogenomics and Toxicoproteomics 2025.
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Gap junctions
- HaCaT
- Keratinocytes
- Pruritus
- STAT3
- Tight junctions
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Toxicology
- General Pharmacology, Toxicology and Pharmaceutics
- Public Health, Environmental and Occupational Health
- Health, Toxicology and Mutagenesis
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