Decursin: A cytotoxic agent and protein kinase C activator from the root of Angelica gigas

Kyung Seop Ahn; Woong Seop Sim; Ik Hwan Kim

doi:10.1055/s-2006-957785

Decursin: A cytotoxic agent and protein kinase C activator from the root of Angelica gigas

Kyung Seop Ahn, Woong Seop Sim, Ik Hwan Kim

Research output: Contribution to journal › Article › peer-review

65 Citations (Scopus)

Abstract

A cytotoxic compound was purified from the root of Angelica gigas Nakai by silica gel chromatography and preparative HPLC. As a result of the structure analysis by mass, IR, ¹H-NMR, and ¹³C-NMR spectrometry, the effective compound was identified as decursin, a pyranocoumarin characterized originally from Angelica decursiva Fr. et Sav. In vitro cytotoxicity testing showed that decursin displayed toxic activity against various human cancer cell lines, for which the ED₅₀ of decursin was about 5-16 μg/ml. On the other hand, decursin displayed relatively low cytotoxicity against normal fibroblasts. Decursin also activated protein kinase C (PKC) in vitro, which indicates that the cytotoxic activity of decursin may be related to the protein kinase C activation.

Original language	English
Pages (from-to)	7-9
Number of pages	3
Journal	Planta Medica
Volume	62
Issue number	1
DOIs	https://doi.org/10.1055/s-2006-957785
Publication status	Published - 1996
Externally published	Yes

Keywords

Angelica gigas Nakai
cytotoxic activity
decursin
protein kinase C activation
umbelliferae

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1055/s-2006-957785

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title = "Decursin: A cytotoxic agent and protein kinase C activator from the root of Angelica gigas",

abstract = "A cytotoxic compound was purified from the root of Angelica gigas Nakai by silica gel chromatography and preparative HPLC. As a result of the structure analysis by mass, IR, 1H-NMR, and 13C-NMR spectrometry, the effective compound was identified as decursin, a pyranocoumarin characterized originally from Angelica decursiva Fr. et Sav. In vitro cytotoxicity testing showed that decursin displayed toxic activity against various human cancer cell lines, for which the ED50 of decursin was about 5-16 μg/ml. On the other hand, decursin displayed relatively low cytotoxicity against normal fibroblasts. Decursin also activated protein kinase C (PKC) in vitro, which indicates that the cytotoxic activity of decursin may be related to the protein kinase C activation.",

keywords = "Angelica gigas Nakai, cytotoxic activity, decursin, protein kinase C activation, umbelliferae",

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T2 - A cytotoxic agent and protein kinase C activator from the root of Angelica gigas

AU - Ahn, Kyung Seop

AU - Sim, Woong Seop

AU - Kim, Ik Hwan

PY - 1996

Y1 - 1996

N2 - A cytotoxic compound was purified from the root of Angelica gigas Nakai by silica gel chromatography and preparative HPLC. As a result of the structure analysis by mass, IR, 1H-NMR, and 13C-NMR spectrometry, the effective compound was identified as decursin, a pyranocoumarin characterized originally from Angelica decursiva Fr. et Sav. In vitro cytotoxicity testing showed that decursin displayed toxic activity against various human cancer cell lines, for which the ED50 of decursin was about 5-16 μg/ml. On the other hand, decursin displayed relatively low cytotoxicity against normal fibroblasts. Decursin also activated protein kinase C (PKC) in vitro, which indicates that the cytotoxic activity of decursin may be related to the protein kinase C activation.

AB - A cytotoxic compound was purified from the root of Angelica gigas Nakai by silica gel chromatography and preparative HPLC. As a result of the structure analysis by mass, IR, 1H-NMR, and 13C-NMR spectrometry, the effective compound was identified as decursin, a pyranocoumarin characterized originally from Angelica decursiva Fr. et Sav. In vitro cytotoxicity testing showed that decursin displayed toxic activity against various human cancer cell lines, for which the ED50 of decursin was about 5-16 μg/ml. On the other hand, decursin displayed relatively low cytotoxicity against normal fibroblasts. Decursin also activated protein kinase C (PKC) in vitro, which indicates that the cytotoxic activity of decursin may be related to the protein kinase C activation.

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KW - protein kinase C activation

KW - umbelliferae

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Decursin: A cytotoxic agent and protein kinase C activator from the root of Angelica gigas

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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