Decursinol angelate: A cytotoxic and protein kinase C activating agent from the root of Angelica gigas

Kyung Seop Ahn; Woong Seop Sim; In Kuk Lee; Young Bae Seu; Ik Hwan Kim

doi:10.1055/s-2006-957701

Decursinol angelate: A cytotoxic and protein kinase C activating agent from the root of Angelica gigas

Kyung Seop Ahn, Woong Seop Sim, In Kuk Lee, Young Bae Seu, Ik Hwan Kim

Department of Biotechnology

Research output: Contribution to journal › Article › peer-review

66 Citations (Scopus)

Abstract

A cytotoxic compound was purified from the root of Angelica gigas Nakai by normal phase HPLC. As a result of the structure analysis by mass, IR, ¹H-NMR, and ¹³C-NMR spectrometry, the compound was identified as decursinol angelate, a structural isomer of decursin, and characterized originally from Sesei grandivittatum. Decursinol angelate showed in vitro cytotoxicity and protein kinase C activating activities like decursin.

Original language	English
Pages (from-to)	360-361
Number of pages	2
Journal	Planta Medica
Volume	63
Issue number	4
DOIs	https://doi.org/10.1055/s-2006-957701
Publication status	Published - 1997

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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abstract = "A cytotoxic compound was purified from the root of Angelica gigas Nakai by normal phase HPLC. As a result of the structure analysis by mass, IR, 1H-NMR, and 13C-NMR spectrometry, the compound was identified as decursinol angelate, a structural isomer of decursin, and characterized originally from Sesei grandivittatum. Decursinol angelate showed in vitro cytotoxicity and protein kinase C activating activities like decursin.",

author = "Ahn, {Kyung Seop} and Sim, {Woong Seop} and Lee, {In Kuk} and Seu, {Young Bae} and Kim, {Ik Hwan}",

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AU - Lee, In Kuk

AU - Seu, Young Bae

AU - Kim, Ik Hwan

PY - 1997

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AB - A cytotoxic compound was purified from the root of Angelica gigas Nakai by normal phase HPLC. As a result of the structure analysis by mass, IR, 1H-NMR, and 13C-NMR spectrometry, the compound was identified as decursinol angelate, a structural isomer of decursin, and characterized originally from Sesei grandivittatum. Decursinol angelate showed in vitro cytotoxicity and protein kinase C activating activities like decursin.

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Decursinol angelate: A cytotoxic and protein kinase C activating agent from the root of Angelica gigas

Abstract

ASJC Scopus subject areas

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