Deformable image registration using a cue-aware deep regression network

Xiaohuan Cao, Jianhua Yang, Jun Zhang, Qian Wang, Pew Thian Yap, Dinggang Shen

Research output: Contribution to journalArticlepeer-review

74 Citations (Scopus)


Significance: Analysis of modern large-scale, multicenter or diseased data requires deformable registration algorithms that can cope with data of diverse nature. Objective: We propose a novel deformable registration method, which is based on a cue-aware deep regression network, to deal with multiple databases with minimal parameter tuning. Methods: Our method learns and predicts the deformation field between a reference image and a subject image. Specifically, given a set of training images, our method learns the displacement vector associated with a pair of reference-subject patches. To achieve this, we first introduce a key-point truncated-balanced sampling strategy to facilitate accurate learning from the image database of limited size. Then, we design a cue-aware deep regression network, where we propose to employ the contextual cue, i.e., the scale-adaptive local similarity, to more apparently guide the learning process. The deep regression network is aware of the contextual cue for accurate prediction of local deformation. Results and Conclusion: Our experiments show that the proposed method can tackle various registration tasks on different databases, giving consistent good performance without the need of manual parameter tuning, which could be applicable to various clinical applications.

Original languageEnglish
Article number8331111
Pages (from-to)1900-1911
Number of pages12
JournalIEEE Transactions on Biomedical Engineering
Issue number9
Publication statusPublished - 2018 Sept


  • Deep learning
  • Deformable registration
  • Key-points sampling
  • Nonlinear regression

ASJC Scopus subject areas

  • Biomedical Engineering


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