Degassed micromolding lithography for rapid fabrication of anisotropic hydrogel microparticles with high-resolution and high uniformity

Hyeon Ung Kim, Yong Jun Lim, Hyun Jee Lee, Nak Jun Lee, Ki Wan Bong

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Replica molding techniques, which are used to synthesize microparticles inside anisotropic micromolds, have been developed to enable the mass production of hydrogel particles. However, these techniques are limited in their ability to synthesize only a narrow range of particle compositions and shapes because of the difficulty in loading precursors into the micromolds as well as the low particle homogeneity due to the uneven evaporation of the precursors. Herein, we describe a simple yet powerful technique, called degassed micromolding lithography, which can load precursors within 1 min regardless of the wettability. This technique is based on the gas-solubility of a degassed micromold that acts as a suction pump to completely fill the mold by drawing precursor liquids in. The semi-closed system within the micromold prevents the uneven evaporation of the precursor, which is essential for the production of homogeneous particles. Furthermore, controlled uniformity of the hydrogel microparticles (C.V. < 2%) can be achieved by engineering the design of the micromold array.

Original languageEnglish
Pages (from-to)74-83
Number of pages10
JournalLab on a Chip
Volume20
Issue number1
DOIs
Publication statusPublished - 2020 Jan 7

Bibliographical note

Funding Information:
This work was supported by the Engineering Research Center of Excellence Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (NRF-2016R1A5A1010148) and the Next-Generation Biogreen 21 Program funded by the Rural Development Administration of Republic of Korea (No. PJ013158). This research was also supported by the Basic Science Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2018R1D1A1B07046577).

Publisher Copyright:
This journal is © The Royal Society of Chemistry.

ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • General Chemistry
  • Biomedical Engineering

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