Delayed puberty due to pituitary stalk dysgenesis and ectopic neurohypophysis

Hye Jin Yoo, Kyung Mook Choi, Ohk Hyun Ryu, Sang Il Suh, Nan Hee Kim, Sei Hyun Baik, Dong Seop Choi

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Hypopituitarism is not a common cause of delayed puberty. A 22 year old man was referred to our clinic because of the absence of the development of secondary sexual characteristics. The patient had no complaints of physical discomfort. Random serum testosterone and luteinizing hormone level were obtained and found to be low. The combined pituitary function stimulation test revealed a partial hypopituitarism. A pituitary magnetic resonance imaging (MRI) was obtained and showed decreased pituitary stalk enhancement and ectopic neurohypophysis. Therefore, we conclude that the delayed puberty was a result of hypopituitarism due to pituitary stalk dysgenesis and ectopic neurohypophysis. The patient was started on hormone replacement therapy and gradually developed secondary sexual characteristics.

Original languageEnglish
Pages (from-to)68-72
Number of pages5
JournalKorean Journal of Internal Medicine
Issue number1
Publication statusPublished - 2006 Mar


  • Delayed puberty
  • Hypopituitarism
  • Neurohypophysis
  • Pituitary stalk

ASJC Scopus subject areas

  • Internal Medicine


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