Beta-amyloid (Aβ) has been suggested to induce neurotoxicity in Alzheimer's disease. We evaluated the neuroprotective effects of delphinidin, an anthocyanidin commonly present in pigmented fruits and vegetables, against Aβ-induced toxicity. Aβ (25-35) significantly decreased the viability of PC12 cells, and this was accompanied by an increase in intracellular calcium levels and tau phosphorylation. However, treatment with delphinidin rescued PC12 cells from Aβ by attenuating the elevation of intracellular calcium levels and tau phosphorylation. Taken together, these results suggest that delphinidin protects PC12 cells against Aβ-induced toxicity by attenuating intracellular calcium influx and tau hyperphosphorylation.
Bibliographical noteFunding Information:
This research was supported by a Grant from the Medical Research Center for Environmental Toxico-Genomics and Proteomics, funded by the Korea Science and Engineering Foundations and the Ministry of Science and Technology.
- Calcium influx
- PC12 cells
- Tau hyperphosphorylation
ASJC Scopus subject areas