Delphinidin ameliorates beta-amyloid-induced neurotoxicity by inhibiting calcium influx and tau hyperphosphorylation

Hyo Shin Kim; Donggeun Sul; Ji Youn Lim; Dongho Lee; Seong Soo Joo; Kwang Woo Hwang; So Young Park

doi:10.1271/bbb.90032

Delphinidin ameliorates beta-amyloid-induced neurotoxicity by inhibiting calcium influx and tau hyperphosphorylation

Hyo Shin Kim, Donggeun Sul, Ji Youn Lim, Dongho Lee, Seong Soo Joo, Kwang Woo Hwang, So Young Park

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Beta-amyloid (Aβ) has been suggested to induce neurotoxicity in Alzheimer's disease. We evaluated the neuroprotective effects of delphinidin, an anthocyanidin commonly present in pigmented fruits and vegetables, against Aβ-induced toxicity. Aβ (25-35) significantly decreased the viability of PC12 cells, and this was accompanied by an increase in intracellular calcium levels and tau phosphorylation. However, treatment with delphinidin rescued PC12 cells from Aβ by attenuating the elevation of intracellular calcium levels and tau phosphorylation. Taken together, these results suggest that delphinidin protects PC12 cells against Aβ-induced toxicity by attenuating intracellular calcium influx and tau hyperphosphorylation.

Original language	English
Pages (from-to)	1685-1689
Number of pages	5
Journal	Bioscience, Biotechnology and Biochemistry
Volume	73
Issue number	7
DOIs	https://doi.org/10.1271/bbb.90032
Publication status	Published - 2009

Bibliographical note

Funding Information:
This research was supported by a Grant from the Medical Research Center for Environmental Toxico-Genomics and Proteomics, funded by the Korea Science and Engineering Foundations and the Ministry of Science and Technology.

Keywords

Beta-amyloid
Calcium influx
Delphinidin
PC12 cells
Tau hyperphosphorylation

ASJC Scopus subject areas

Medicine(all)

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10.1271/bbb.90032

Cite this

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title = "Delphinidin ameliorates beta-amyloid-induced neurotoxicity by inhibiting calcium influx and tau hyperphosphorylation",

abstract = "Beta-amyloid (Aβ) has been suggested to induce neurotoxicity in Alzheimer's disease. We evaluated the neuroprotective effects of delphinidin, an anthocyanidin commonly present in pigmented fruits and vegetables, against Aβ-induced toxicity. Aβ (25-35) significantly decreased the viability of PC12 cells, and this was accompanied by an increase in intracellular calcium levels and tau phosphorylation. However, treatment with delphinidin rescued PC12 cells from Aβ by attenuating the elevation of intracellular calcium levels and tau phosphorylation. Taken together, these results suggest that delphinidin protects PC12 cells against Aβ-induced toxicity by attenuating intracellular calcium influx and tau hyperphosphorylation.",

keywords = "Beta-amyloid, Calcium influx, Delphinidin, PC12 cells, Tau hyperphosphorylation",

author = "Kim, {Hyo Shin} and Donggeun Sul and Lim, {Ji Youn} and Dongho Lee and Joo, {Seong Soo} and Hwang, {Kwang Woo} and Park, {So Young}",

note = "Funding Information: This research was supported by a Grant from the Medical Research Center for Environmental Toxico-Genomics and Proteomics, funded by the Korea Science and Engineering Foundations and the Ministry of Science and Technology.",

year = "2009",

doi = "10.1271/bbb.90032",

language = "English",

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AU - Kim, Hyo Shin

AU - Sul, Donggeun

AU - Lim, Ji Youn

AU - Lee, Dongho

AU - Joo, Seong Soo

AU - Hwang, Kwang Woo

AU - Park, So Young

N1 - Funding Information: This research was supported by a Grant from the Medical Research Center for Environmental Toxico-Genomics and Proteomics, funded by the Korea Science and Engineering Foundations and the Ministry of Science and Technology.

PY - 2009

Y1 - 2009

N2 - Beta-amyloid (Aβ) has been suggested to induce neurotoxicity in Alzheimer's disease. We evaluated the neuroprotective effects of delphinidin, an anthocyanidin commonly present in pigmented fruits and vegetables, against Aβ-induced toxicity. Aβ (25-35) significantly decreased the viability of PC12 cells, and this was accompanied by an increase in intracellular calcium levels and tau phosphorylation. However, treatment with delphinidin rescued PC12 cells from Aβ by attenuating the elevation of intracellular calcium levels and tau phosphorylation. Taken together, these results suggest that delphinidin protects PC12 cells against Aβ-induced toxicity by attenuating intracellular calcium influx and tau hyperphosphorylation.

AB - Beta-amyloid (Aβ) has been suggested to induce neurotoxicity in Alzheimer's disease. We evaluated the neuroprotective effects of delphinidin, an anthocyanidin commonly present in pigmented fruits and vegetables, against Aβ-induced toxicity. Aβ (25-35) significantly decreased the viability of PC12 cells, and this was accompanied by an increase in intracellular calcium levels and tau phosphorylation. However, treatment with delphinidin rescued PC12 cells from Aβ by attenuating the elevation of intracellular calcium levels and tau phosphorylation. Taken together, these results suggest that delphinidin protects PC12 cells against Aβ-induced toxicity by attenuating intracellular calcium influx and tau hyperphosphorylation.

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KW - Calcium influx

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KW - PC12 cells

KW - Tau hyperphosphorylation

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JO - Bioscience, Biotechnology and Biochemistry

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Delphinidin ameliorates beta-amyloid-induced neurotoxicity by inhibiting calcium influx and tau hyperphosphorylation

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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