Dengue-associated hemophagocyticlymphohistiocytosis in an adult A case report and literature review

Sang Mi Chung; Joon Young Song; Wonshik Kim; Min Joo Choi; Ji Ho Jeon; Seonghui Kang; Eunju Jung; Ji Yun Noh; Hee Jin Cheong; Woo Joo Kim

doi:10.1097/MD.0000000000006159

Dengue-associated hemophagocyticlymphohistiocytosis in an adult A case report and literature review

Sang Mi Chung, Joon Young Song, Wonshik Kim, Min Joo Choi, Ji Ho Jeon, Seonghui Kang, Eunju Jung, Ji Yun Noh, Hee Jin Cheong, Woo Joo Kim

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Background: Infection-associated hemophagocytic syndrome (IAHS) is potentially a fatal disease caused by systemic infection complicated by hemophagocyticlymphohistiocytosis (HLH). Here, we report a case of HLH associated with dengue hemorrhagic fever (DHF) after a trip to Thailand. Case summary: A 33-year-old healthy female patient presented with 3 days of fever, myalgia, and skin rash. Serotype 3 dengue virus was isolated. Clinical and laboratory findings fulfilled the criteria of HLH. After the initiation of corticosteroid therapy, the patient recovered and laboratory findings were normalized. Conclusion: It would be important to differentially diagnose dengue-associated HLH from severe DHF. Early recognition and initiation of steroid treatment would be crucial for the successful treatment of dengue fever complicated by HLH.

Original language	English
Article number	e6159
Journal	Medicine (United States)
Volume	96
Issue number	8
DOIs	https://doi.org/10.1097/MD.0000000000006159
Publication status	Published - 2017
Externally published	Yes

Keywords

Corticosteroid
Dengue hemorrhagic fever
Hemophagocyticlymphohistiocytosis
Severe dengue

ASJC Scopus subject areas

Medicine(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/MD.0000000000006159

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title = "Dengue-associated hemophagocyticlymphohistiocytosis in an adult A case report and literature review",

abstract = "Background: Infection-associated hemophagocytic syndrome (IAHS) is potentially a fatal disease caused by systemic infection complicated by hemophagocyticlymphohistiocytosis (HLH). Here, we report a case of HLH associated with dengue hemorrhagic fever (DHF) after a trip to Thailand. Case summary: A 33-year-old healthy female patient presented with 3 days of fever, myalgia, and skin rash. Serotype 3 dengue virus was isolated. Clinical and laboratory findings fulfilled the criteria of HLH. After the initiation of corticosteroid therapy, the patient recovered and laboratory findings were normalized. Conclusion: It would be important to differentially diagnose dengue-associated HLH from severe DHF. Early recognition and initiation of steroid treatment would be crucial for the successful treatment of dengue fever complicated by HLH.",

keywords = "Corticosteroid, Dengue hemorrhagic fever, Hemophagocyticlymphohistiocytosis, Severe dengue",

author = "Chung, {Sang Mi} and Song, {Joon Young} and Wonshik Kim and Choi, {Min Joo} and Jeon, {Ji Ho} and Seonghui Kang and Eunju Jung and Noh, {Ji Yun} and Cheong, {Hee Jin} and Kim, {Woo Joo}",

note = "Funding Information: This work was supported by the National Research Foundation of Korea(NRF) Grant funded by the Korean Government(MSIP)(NRF-2016R1A5A1010148). Publisher Copyright: {\textcopyright} 2017 the Author(s). Published by Wolters Kluwer Health, Inc.",

year = "2017",

doi = "10.1097/MD.0000000000006159",

language = "English",

volume = "96",

journal = "Medicine; analytical reviews of general medicine, neurology, psychiatry, dermatology, and pediatries",

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publisher = "Lippincott Williams and Wilkins",

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TY - JOUR

T1 - Dengue-associated hemophagocyticlymphohistiocytosis in an adult A case report and literature review

AU - Chung, Sang Mi

AU - Song, Joon Young

AU - Kim, Wonshik

AU - Choi, Min Joo

AU - Jeon, Ji Ho

AU - Kang, Seonghui

AU - Jung, Eunju

AU - Noh, Ji Yun

AU - Cheong, Hee Jin

AU - Kim, Woo Joo

N1 - Funding Information: This work was supported by the National Research Foundation of Korea(NRF) Grant funded by the Korean Government(MSIP)(NRF-2016R1A5A1010148). Publisher Copyright: © 2017 the Author(s). Published by Wolters Kluwer Health, Inc.

PY - 2017

Y1 - 2017

N2 - Background: Infection-associated hemophagocytic syndrome (IAHS) is potentially a fatal disease caused by systemic infection complicated by hemophagocyticlymphohistiocytosis (HLH). Here, we report a case of HLH associated with dengue hemorrhagic fever (DHF) after a trip to Thailand. Case summary: A 33-year-old healthy female patient presented with 3 days of fever, myalgia, and skin rash. Serotype 3 dengue virus was isolated. Clinical and laboratory findings fulfilled the criteria of HLH. After the initiation of corticosteroid therapy, the patient recovered and laboratory findings were normalized. Conclusion: It would be important to differentially diagnose dengue-associated HLH from severe DHF. Early recognition and initiation of steroid treatment would be crucial for the successful treatment of dengue fever complicated by HLH.

AB - Background: Infection-associated hemophagocytic syndrome (IAHS) is potentially a fatal disease caused by systemic infection complicated by hemophagocyticlymphohistiocytosis (HLH). Here, we report a case of HLH associated with dengue hemorrhagic fever (DHF) after a trip to Thailand. Case summary: A 33-year-old healthy female patient presented with 3 days of fever, myalgia, and skin rash. Serotype 3 dengue virus was isolated. Clinical and laboratory findings fulfilled the criteria of HLH. After the initiation of corticosteroid therapy, the patient recovered and laboratory findings were normalized. Conclusion: It would be important to differentially diagnose dengue-associated HLH from severe DHF. Early recognition and initiation of steroid treatment would be crucial for the successful treatment of dengue fever complicated by HLH.

KW - Corticosteroid

KW - Dengue hemorrhagic fever

KW - Hemophagocyticlymphohistiocytosis

KW - Severe dengue

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DO - 10.1097/MD.0000000000006159

M3 - Article

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AN - SCOPUS:85015599555

SN - 0025-7974

VL - 96

JO - Medicine; analytical reviews of general medicine, neurology, psychiatry, dermatology, and pediatries

JF - Medicine; analytical reviews of general medicine, neurology, psychiatry, dermatology, and pediatries

IS - 8

M1 - e6159

ER -

Dengue-associated hemophagocyticlymphohistiocytosis in an adult A case report and literature review

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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